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Articles Published Processes
10/1/2014 8:25:00 PM | Browse: 1293 | Download: 1674
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Received |
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2014-01-27 10:26 |
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Peer-Review Started |
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2014-01-27 15:29 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-03-06 19:59 |
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Revised |
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2014-03-30 23:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-06-26 17:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-06-26 17:23 |
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Articles in Press |
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2014-06-26 17:52 |
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Edit the Manuscript by Language Editor |
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2014-08-13 07:08 |
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Typeset the Manuscript |
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2014-09-12 08:35 |
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Publish the Manuscript Online |
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2014-10-01 20:25 |
| Category |
Cell Biology |
| Manuscript Type |
Autobiography |
| Article Title |
Reversible immortalization of human hepatocytes mediated by retroviral transfer and site-specific recombination
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fan-Ying Meng, Li Liu, Feng-Hui Yang, Chun-You Li, Jun Liu and Ping Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major Scientific and Technological Project of Shandong Province |
201221019 |
| Cisco Clinical Oncology Research Fund and Bayer Schering Cancer Research Fund |
Y-B2012-011 |
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| Corresponding Author |
Jun Liu, MD, PhD, Division of Hepato-Biliary-Pancreatic Surgery, Institute of Organ Transplantation, Shandong Provincial Hospital Affiliated to Shandong University, Jingwuwei 7 Road 324, Jinan 250021, Shandong Province, China. 963cat@sohu.com |
| Key Words |
Hepatocyte; Primary human hepatocytes; Reversible immortalization; Hepatocyte isolation; SV40T |
| Core Tip |
It is meaningful to establish reversibly immortalized human hepatocytes which can be economically grown in tissue culture. Toward this goal, we successfully established a method for the reversible immortalization of human hepatocytes using Cre/loxP site-specific recombination, which may offer a good and safe source of hepatocytes for the bioartificial liver (BAL) system in the near future. If a sufficient number of human hepatocytes can be used, these extracorporeal devices will serve as successful “bridge-to-transplant”therapies. With the progress made in bioreactor development, the next-generation BAL system could reach the level of artificial kidney and save more patients. |
| Publish Date |
2014-10-01 20:25 |
| Citation |
Meng FY, Liu L, Yang FH, Li CY, Liu J, Zhou P. Reversible immortalization of human hepatocytes mediated by retroviral transfer and site-specific recombination. World J Gastroenterol 2014; 20(36): 13119-13126 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i36/13119.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i36.13119 |
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