Publication Name	World Journal of Gastroenterology
Manuscript ID	92037
Country	China

Received	2024-01-13 09:47
Peer-Review Started	2024-01-13 09:47
To Make the First Decision
Return for Revision	2024-02-26 03:06
Revised	2024-03-05 04:40
Second Decision	2024-04-25 02:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-25 06:18
Articles in Press	2024-04-25 06:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-10 09:19
Publish the Manuscript Online	2024-05-20 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells
Manuscript Source	Unsolicited Manuscript
All Author List	Yang Gao, Li Li, Sheng-Ning Zhang, Yuan-Yi Mang, Xi-Bing Zhang and Shi-Ming Feng
ORCID	Author(s) ORCID Number Li Li http://orcid.org/0009-0005-4372-4011
Funding Agency and Grant Number	Funding Agency Grant Number The Spring City Plan: The High-level Talent Promotion and Training Project of Kunming 2022SCP002 The Research of Key Techniques and Application of Liver-Kidney Organ Transplantation 202302AA310018
Corresponding Author	Li Li, MD, Chief Physician, Department of Hepatobiliary Pancreatic and Vascular Surgery, The Affiliated Calmette Hospital of Kunming Medical University and The First Hospital of Kunming, No. 504 Qingnian Road, Kunming 650011, Yunnan Province, China. kmlili557@163.com
Key Words	Hepatic stellate cells; Liver fibrosis; Exosomes; Small RNA sequencing; HepG2.2.15
Core Tip	This study investigated the effects of exosomes, particularly those derived from HepG2.2.15 cells, on the activation of LX2 stellate cells and the progression of liver fibrosis. Exosomes from HepG2.2.15 cells been found to enhance LX2 cell activation, proliferation, and fibrosis. These exosomes contained 27 differentially expressed microRNAs that target various cellular functions and pathways, including differentiation, signal transduction, and apoptosis regulation. This suggests a significant role for HepG2.2.15-derived exosomes in liver fibrosis, with potential therapeutic implications.
Publish Date	2024-05-20 09:15
Citation	<p>Gao Y, Li L, Zhang SN, Mang YY, Zhang XB, Feng SM. HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells. <i>World J Gastroenterol</i> 2024; 30(19): 2553-2563</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i19/2553.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i19.2553

Full Article (PDF)	WJG-30-2553-with-cover.pdf
Manuscript File	92037_Auto_Edited-YJP.docx
Answering Reviewers	92037-Answering reviewers.pdf
Audio Core Tip	92037-Audio core tip.MP3
Biostatistics Review Certificate	92037-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92037-Conflict-of-interest statement.pdf
Copyright License Agreement	92037-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92037-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	92037-Institutional review board statement.pdf
Institutional Review Board Approval Form or Document	92037-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	92037-Language certificate.pdf
Supplementary Material	92037-Supplementary material.pdf
Peer-review Report	92037-Peer-review(s).pdf
Scientific Misconduct Check	92037-Bing-Fan JR-2.png
Scientific Editor Work List	92037-Scientific editor work list.pdf
CrossCheck Report	92037-CrossCheck report.pdf
CrossCheck Report	92037-CrossCheck.png