Publication Name	World Journal of Gastroenterology
Manuscript ID	9205
Country	China

Received	2014-01-26 08:01
Peer-Review Started	2014-01-26 08:45
To Make the First Decision	2014-02-14 16:53
Return for Revision	2014-02-18 21:39
Revised	2014-03-09 09:30
Second Decision	2014-04-16 11:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 11:39
Articles in Press	2014-05-23 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-03 02:34
Typeset the Manuscript	2014-07-02 18:36
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Abdominoperineal excision following preoperative radiotherapy for rectal cancer: Unfavorable prognosis even with negative circumferential resection margin
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Wang, Guo-Li Gu, Zhong-Wu Li, Yi-Fan Peng and Jin Gu
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ZY201410
Corresponding Author	Jin Gu, MD, FACS, Department of Colorectal Surgery, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, 52 Fuchenglu Road, Beijing 100142, China. zlgujin@126.com
Key Words	Abdominoperineal excision; Preoperative radiotherapy; Circumferential resection margin; Survival
Core Tip	The present study focused on survival differences between rectal cancer treated with abdominoperineal excision or non-abdominoperineal excision (APE) following preoperative radiotherapy, with the adjustments of the circumferential resection margin (CRM) to preclude the influence of surgical radicality. The results revealed the more aggressive oncological behavior of low-lying or fixed tumors, which were unavailable for the sphincter preservation procedure even with negative CRM. We also emphasized the importance of preoperative staging and decision-making before APE procedure, and reviewed the related hypotheses for the unfavorable local control of APE in the discussion.
Publish Date	2014-07-21 17:17
Citation	Wang L, Gu GL, Li ZW, Peng YF, Gu J. Abdominoperineal excision following preoperative radiotherapy for rectal cancer: Unfavorable prognosis even with negative circumferential resection margin. World J Gastroenterol 2014; 20(27): 9138-9145
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/9138.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.9138

Full Article (PDF)	WJG-20-9138.pdf
Full Article (Word)	WJG-20-9138.doc
Manuscript File	9205-Review.docx
Answering Reviewers	9205-Answering reviewers.pdf
Copyright License Agreement	9205-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9205-Language certificate.pdf
Peer-review Report	9205-Peer review.pdf
Scientific Editor Work List	9205-Scientific editor work list.doc