| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Irina Efremova, Roman Maslennikov, Elena Poluektova, Oleg Medvedev, Anna Kudryavtseva, George Krasnov, Maria Fedorova, Filipp Romanikhin, Maria Zharkova, Oxana Zolnikova, Gyunay Bagieva and Vladimir Ivashkin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Roman Maslennikov, MD, PhD, Academic Editor, Associate Professor, Doctor, Doctor, Professor, Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya str., 1, bld. 1, Moscow, 119435, Russian Federation.
, Moscow 119435, Russia. mmmm00@yandex.ru |
| Key Words |
Dysbiosis; Gut; Intestinal permeability; Leaky gut; Gut-liver axis; Liver; Microbiota |
| Core Tip |
The gut–liver axis and bacterial translocation are important in cirrhosis; however, there is no available universal biomarker for cellular bacterial translocation, although presepsin may be a candidate. The level of presepsin directly correlated with the abundance in the gut microbiota of the main taxa that are substrates of bacterial translocation in cirrhosis. This biomarker, in the absence of obvious infection, seems important for assessing the state of the gut–liver axis in cirrhosis to decide on therapy targeted at the gut microbiota in this disease. |
| Publish Date |
2024-05-22 11:33 |
| Citation |
<p>Efremova I, Maslennikov R, Poluektova E, Medvedev O, Kudryavtseva A, Krasnov G, Fedorova M, Romanikhin F, Zharkova M, Zolnikova O, Bagieva G, Ivashkin V. Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis. <i>World J Hepatol</i> 2024; 16(5): 822-831</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i5/822.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i5.822 |
