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Articles Published Processes
4/25/2024 5:24:45 AM | Browse: 108 | Download: 360
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Received |
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2024-01-15 16:10 |
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Peer-Review Started |
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2024-01-15 16:10 |
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To Make the First Decision |
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Return for Revision |
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2024-01-29 21:00 |
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Revised |
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2024-02-11 09:35 |
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Second Decision |
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2024-03-14 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-03-14 04:36 |
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Articles in Press |
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2024-03-14 04:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-04-17 13:09 |
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Publish the Manuscript Online |
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2024-04-25 05:24 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Jin Ai, Ling-Juan Chen, Li-Xuan Guo, Ya-Ping Wang and Zi-Yi Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zi-Yi Zhao, PhD, Professor, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Shi-er-qiao Road, Chengdu 641000, Sichuan Province, China. zhaoziyi@cdutcm.edu.cn |
| Key Words |
Leukemia stem cells; Gossypol acetic acid; Reactive oxygen species; Mitochondrial dysfunction; Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling |
| Core Tip |
Gossypol acetic acid (GAA) inhibited janus kinase 1/signal transducer and activator of transcription 3 signaling activated by interleukin 6 in leukemia stem cells (LSCs). GAA sensitizes to chemoagent, including cytarabine, Dexamethasone and L-Asparaginase in LSCs. GAA decreased leucine-rich pentatricopeptide repeat-containing protein and subsequent downregulated forkhead box M1, which are critical and necessary for stemness of LSCs. GAA induces mitochondrial dysfunction via inducing reactive oxygen species accumulation. GAA might eliminate the effects of inflammatory environment on LSCs. |
| Publish Date |
2024-04-25 05:24 |
| Citation |
Ai CJ, Chen LJ, Guo LX, Wang YP, Zhao ZY. Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction. World J Stem Cells 2024; 16(4): 444-458 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i4/444.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i4.444 |
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