| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Yang, Yu-Ting Qiu, Wen-Kun Li, Zi-Lu Cui, Shuo Teng, Ya-Dan Wang and Jing Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Science and Technology Program |
Z211100002921028 |
| Capital’s Funds for Health Improvement and Research |
CFH2022-2-2025 |
|
| Corresponding Author |
Jing Wu, Consultant, MD, PhD, Dean, Doctor, Doctor, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, No. 59 Yong’an Road, Xicheng District, Beijing 100050, China. wujing36youyi@ccmu.edu.cn |
| Key Words |
Angiogenesis; Colon cancer; Immunotherapy; K-means; Single-cell analysis |
| Core Tip |
Angiogenesis plays an important role in colon cancer (CC) progression. This study identified two angiogenesis subtypes (AGSs) with significantly different prognoses, tumor microenvironment, intratumor microbiota, drug sensitivity, and cancer-related pathways single-sample gene set enrichment analysis scores in patients with CC. Based on the two AGSs, a convenient 6-gene angiogenesis-related signature (ARS), was established to predict the prognosis in CC patients. SLC2A3 was selected as the representative gene of ARS, which was higher expressed in endothelial cells and promoted the migration of HUVECs. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
<p>Yang Y, Qiu YT, Li WK, Cui ZL, Teng S, Wang YD, Wu J. Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3169-3192</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3169.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3169 |
