Publication Name	World Journal of Stem Cells
Manuscript ID	92184
Country	Taiwan

Received	2024-01-18 02:40
Peer-Review Started	2024-01-18 02:40
To Make the First Decision
Return for Revision	2024-03-09 06:25
Revised	2024-04-08 07:41
Second Decision	2024-05-07 02:34
Accepted by Journal Editor-in-Chief	2024-05-08 22:08
Accepted by Executive Editor-in-Chief	2024-05-09 05:20
Articles in Press	2024-05-09 05:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-15 09:38
Publish the Manuscript Online	2024-06-25 10:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis
Manuscript Source	Unsolicited Manuscript
All Author List	Kun-Chen Lin, Wen-Feng Fang, Jui-Ning Yeh, John Y Chiang, Hsin-Ju Chiang, Pei-Lin Shao, Pei-Hsun Sung and Hon-Kan Yip
ORCID	Author(s) ORCID Number Pei-Hsun Sung http://orcid.org/0000-0002-1989-9752 Hon-Kan Yip http://orcid.org/0000-0002-6305-5717
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology, Taiwan MOST 110-2314-B-182A-133-
Corresponding Author	Hon-Kan Yip, MD, Chief Doctor, Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123 Dapi Road, Niaosung District, Kaohsiung 83301, Taiwan. han.gung@msa.hinet.net
Key Words	Acute respiratory distress syndrome; Sepsis syndrome; Exosomes; Mitochondria; Adipose tissue-derived mesenchymal stem cells; Inflammation
Core Tip	To investigate whether combined adipose-derived mesenchymal-stem-cells-derived exosome (EXAD) and exogenous mitochondria (mitoEx) protect the lung from acute respiratory distress syndrome complicated by sepsis syndrome. The results of this study showed that combined EXAD and mitoEx exerted a synergic effect on protecting the lung from acute respiratory distress syndrome complicated by sepsis syndrome mainly by suppressing inflammatory reaction and oxidative stress, resulting in improved respiratory system and outcomes.
Publish Date	2024-06-25 10:11
Citation	<p>Lin KC, Fang WF, Yeh JN, Chiang JY, Chiang HJ, Shao PL, Sung PH, Yip HK. Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis. <i>World J Stem Cells</i> 2024; 16(6): 690-707</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i6/690.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i6.690

Full Article (PDF)	WJSC-16-690-with-cover.pdf
The ARRIVE Guidelines	92184-The-ARRIVE-Guidelines.pdf
Manuscript File	92184_Auto_Edited-YJP.docx
Answering Reviewers	92184-answering-reviewers.pdf
Audio Core Tip	92184-audio.m4a
Biostatistics Review Certificate	92184-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	92184-conflict-of-interest-statement.pdf
Copyright License Agreement	92184-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92184-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	92184-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	92184-non-native-speakers.pdf
Supplementary Material	92184-supplementary-material.pdf
Peer-review Report	92184-peer-reviews.pdf
Journal Editor-in-Chief Review Report	92184-journal-editor-in-chief.pdf
Scientific Misconduct Check	92184-scientific-misconduct-check.png
Scientific Editor Work List	92184-scientific-editor-work-list.pdf
CrossCheck Report	92184-crosscheck-report.pdf