Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	92194
Country	France

Received	2024-01-18 09:40
Peer-Review Started	2024-01-18 09:40
To Make the First Decision
Return for Revision	2024-03-09 03:05
Revised	2024-04-04 08:56
Second Decision	2024-05-21 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-21 06:17
Articles in Press	2024-05-21 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-15 09:48
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Role of molecular biology in the management of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Alice Boileve, Cristina Smolenschi, Aurélien Lambert, Valérie Boige, Anthony Tarabay, Marine Valery, Alina Fuerea, Thomas Pudlarz, Thierry Conroy, Antoine Hollebecque and Michel Ducreux
ORCID	Author(s) ORCID Number Alice Boileve http://orcid.org/0000-0003-3708-4909 Anthony Tarabay http://orcid.org/0000-0002-3804-3554
Funding Agency and Grant Number
Corresponding Author	Alice Boileve, MD, Assistant Professor, Department of Medical, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif 94800, France. alice.boileve@gustaveroussy.fr
Key Words	Pancreatic cancer; Precision medicine; KRAS; Molecular profile; Targeted therapies; Liquid biopsy
Core Tip	Management of patients with pancreatic cancer (PDAC) is a real challenge due to a poor prognosis, a rising incidence and few therapeutic options. Precision medicine is an approach that seeks to personalize treatments to the specific molecular characteristics of individual tumors. Despite a growing interest in applying molecular precision medicine for PDAC management, large scale precision medicine is not endorsed so far by the last recommendations. We review the main actionable molecular alterations found in PDAC, highlighting the differences between KRAS-mutated and KRAS-wild-type tumors, as well as precision medicine in clinical practice and future directions for precision medicine in PDAC.
Publish Date	2024-07-12 15:55
Citation	<p>Boileve A, Smolenschi C, Lambert A, Boige V, Tarabay A, Valery M, Fuerea A, Pudlarz T, Conroy T, Hollebecque A, Ducreux M. Role of molecular biology in the management of pancreatic cancer. <i>World J Gastrointest Oncol</i> 2024; 16(7): 2902-2914</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/2902.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.2902

Full Article (PDF)	WJGO-16-2902-with-cover.pdf
Manuscript File	92194_Auto_Edited-YJP.docx
Answering Reviewers	92194-answering-reviewers.pdf
Audio Core Tip	92194-audio.m4a
Conflict-of-Interest Disclosure Form	92194-conflict-of-interest-statement.pdf
Copyright License Agreement	92194-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	92194-non-native-speakers.pdf
Peer-review Report	92194-peer-reviews.pdf
Scientific Misconduct Check	92194-scientific-misconduct-check.png
Scientific Editor Work List	92194-scientific-editor-work-list.pdf
CrossCheck Report	92194-crosscheck-report.pdf