Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	92204
Country	China

Received	2024-01-18 14:16
Peer-Review Started	2024-01-18 14:16
To Make the First Decision
Return for Revision	2024-01-26 04:48
Revised	2024-02-02 14:33
Second Decision	2024-03-13 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-13 07:12
Articles in Press	2024-03-13 07:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 05:35
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Clinical and Translational Research
Article Title	Casual associations between blood metabolites and colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Yue Hu, Yi-Quan Cheng, Zhi-Long Shi, Fu-Peng Ren and Gang-Feng Xiao
ORCID	Author(s) ORCID Number Gang-Feng Xiao http://orcid.org/0009-0002-2807-6771
Funding Agency and Grant Number	Funding Agency Grant Number the General Project of Medical and Health Technology Plan of Zhejiang Province 2020KY845
Corresponding Author	Gang-Feng Xiao, MD, PhD, Doctor, Doctor, Department of Hematology and Oncology, Ningbo No. 2 Hospital, Ningbo 315000, Zhejiang Province, China. ducan11@163.com
Key Words	Metabolites; Colon cancer; Mendelian randomization; Genome-wide association studies; Casual
Core Tip	The study utilized a two-sample Mendelian randomization analysis to investigate the causal impact of 486 blood metabolites on colorectal cancer. The primary method of analysis used was the inverse variance weighted model. To further validate the results several sensitivity analyses were performed. Our findings showed a causal relationship between 10 blood metabolites and colorectal cancer, of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk factors.
Publish Date	2024-05-09 13:59
Citation	Hu KY, Cheng YQ, Shi ZL, Ren FP, Xiao GF. Casual associations between blood metabolites and colon cancer. World J Gastrointest Oncol 2024; 16(5): 1995-2005
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/1995.htm
DOI	10.4251/wjgo.v16.i5.1995

Full Article (PDF)	WJGO-16-1995-with-cover.pdf
Manuscript File	92204_Auto_Edited-YJP.docx
Answering Reviewers	92204-Answering reviewers.pdf
Audio Core Tip	92204-Audio core tip.m4a
Biostatistics Review Certificate	92204-Biostatistics statement.pdf
Clinical Trial Registration Statement	92204-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	92204-Conflict-of-interest statement.pdf
Copyright License Agreement	92204-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92204-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	92204-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	92204-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	92204-Language certificate.pdf
Supplementary Material	92204-Supplementary material.pdf
Peer-review Report	92204-Peer-review(s).pdf
Scientific Misconduct Check	92204-Bing-Li L-2.png
Scientific Editor Work List	92204-Scientific editor work list.pdf
CrossCheck Report	92204-CrossCheck.png
CrossCheck Report	92204-CrossCheck report.pdf