Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	92255
Country	China

Received	2024-01-20 07:29
Peer-Review Started	2024-01-20 07:29
To Make the First Decision
Return for Revision	2024-04-09 20:36
Revised	2024-04-29 09:23
Second Decision	2024-06-04 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-04 06:50
Articles in Press	2024-06-04 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-06-11 14:55
Typeset the Manuscript	2024-06-19 00:22
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Baitouweng decoction suppresses the growth of esophageal carcinoma cells through the miR-495-3p/BUB1/STAT3 axis
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Yang, Xiao-Wei Chen, Xue-Jie Song, Hai-Yang Du and Fu-Chun Si
ORCID	Author(s) ORCID Number Hui Yang http://orcid.org/0000-0002-5286-0956 Fu-Chun Si http://orcid.org/0000-0002-9880-7333
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81550014 Henan Provincial Science and Technology Research Project 222102310187 Henan Provincial Science and Technology Research Project 242102310582 Henan Province Postdoctoral Research Project 202103092
Corresponding Author	Fu-Chun Si, PhD, Professor, Henan Key Laboratory of Traditional Chinese Medicine Syndrome and Prescription in Signaling, Henan International Joint Laboratory of TCM Syndrome and Prescription in Signaling, Traditional Chinese medicine School, Henan University of Chinese Medicine, No. 156 Jinshui East Road, Zhengdong New District, Zhengzhou 450046, Henan Province, China. sifc2000@hotmail.com
Key Words	Baitouweng decoction; Esophageal cancer; miR-495-3p, BUB1; STAT3 signaling pathway
Core Tip	Differentially expressed genes of esophageal carcinoma (EC) were analyzed and BUB1 was found to be a key hub gene. BUB1 is a target gene of miR-495-3p, and BUB1 can directly interact with STAT3 to inhibit tumor cell proliferation. We studied the effects of Baitouweng decoction on the cell cycle, apoptosis, migration and invasion, and further investigated the inhibitory effect of Baitouweng decoction on the development of EC by targeting BUB1 and STAT3 via miR-495-3p. The potential functional pathways were explored.
Publish Date	2024-07-12 15:55
Citation	<p>Yang H, Chen XW, Song XJ, Du HY, Si FC. Baitouweng decoction suppresses the growth of esophageal carcinoma cells through the miR-495-3p/BUB1/STAT3 axis. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3193-3210</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/3193.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.3193

Full Article (PDF)	WJGO-16-3193-with-cover.pdf
Manuscript File	92255_Auto_Edited-YJP_WangTQ.docx
Answering Reviewers	92255-answering-reviewers.pdf
Audio Core Tip	92255-audio.mp3
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Non-Native Speakers of English Editing Certificate	92255-non-native-speakers.pdf
Peer-review Report	92255-peer-reviews.pdf
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Scientific Editor Work List	92255-scientific-editor-work-list.pdf
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CrossCheck Report	92255-crosscheck-report.pdf