Publication Name	World Journal of Gastroenterology
Manuscript ID	9227
Country	China

Received	2014-01-27 12:18
Peer-Review Started	2014-01-28 21:45
To Make the First Decision	2014-02-27 13:34
Return for Revision	2014-03-11 11:37
Revised	2014-03-17 01:13
Second Decision	2014-04-29 12:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 14:16
Articles in Press	2014-05-23 09:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-12 22:33
Typeset the Manuscript	2014-06-27 17:06
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Clinical Trials Study
Article Title	Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Ma, Ayshamgul Hasim, Batur Mamtimin, Bin Kong, Hai-Ping Zhang and Ilyar Sheyhidin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81360356 Scientific Research Foundation of Xinjiang Medical University XJC201221
Corresponding Author	Ilyar Sheyhidin, Professor, Department of Thoracic Surgery, The First Affiliated Hospital, Medical University of Xinjiang, 137 Liyushan Road, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China. ilyarsha@hotmail.com
Key Words	Metabolomics; High-performance liquid chromatography; Esophageal squamous cell cancer; Plasma; Amino acids
Core Tip	Recently, metabolomics-based techniques have been developed to identify cancer-related metabolic signatures for early cancer detection. However, studies on esophageal squamous cell carcinoma (ESCC) remain limited. This study used high-performance liquid chromatography to quantitatively study plasma free amino acid (PFAA) changes in ESCC patient, and analyze the correlation between PFAA profiles and clinicopathological characteristics of ESCC. The results showed that most of the amino acids were differentially expressed in ESCC patients and control subjects, and were related to the ESCC clinicopathological characteristics. The study suggests that PFAA profiling is of potential value for screening or diagnosing ESCC.
Publish Date	2014-07-14 17:39
Citation	Ma H, Hasim A, Mamtimin B, Kong B, Zhang HP, Sheyhidin I. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy. World J Gastroenterol 2014; 20(26): 8653-8659
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8653.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8653

Full Article (PDF)	WJG-20-8653.pdf
Full Article (Word)	WJG-20-8653.doc
Manuscript File	9227-Review.doc
Answering Reviewers	9227-Answering reviewers.pdf
Copyright License Agreement	9227-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9227-Language certificate.pdf
Peer-review Report	9227-Peer review.pdf
Scientific Editor Work List	9227-Scientific editor work list.pdf