Publication Name	World Journal of Gastroenterology
Manuscript ID	92303
Country	Italy

Received	2024-01-21 20:12
Peer-Review Started	2024-01-21 20:12
To Make the First Decision
Return for Revision	2024-02-06 20:17
Revised	2024-02-28 22:45
Second Decision	2024-04-16 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-16 05:52
Articles in Press	2024-04-16 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-29 16:29
Publish the Manuscript Online	2024-05-11 10:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Overlapping approach PPIs/Nux vomica-Heel as new intervention model in the management of GERD: A Delphi consensus study
Manuscript Source	Unsolicited Manuscript
All Author List	Edda Battaglia, Luciano Bertolusso, Marco Del Prete, Marco Monzani and Marco Astegiano
ORCID	Author(s) ORCID Number Edda Battaglia http://orcid.org/0000-0002-0670-9120
Funding Agency and Grant Number	Funding Agency Grant Number Guna S.p.a. (unconditional granted)
Corresponding Author	Edda Battaglia, MD, Director, Director, Gastroenterology Unit, ASLTO4, Ivrea, Piazza Credenza 2, Turin 10034, Italy. edda.battaglia@gmail.com
Key Words	Gastro-esophageal reflux disease; Proton pump inhibitors; Consensus; Nux vomica-heel; Overlapping; Decalage
Core Tip	This Delphi consensus suggests Nux vomica-Heel as a new therapeutic tool for the Medical Doctor (MD) who daily finds himself diagnosing and treating Gastro-Esophageal Reflux Disease (GERD). Nux vomica-Heel is multicomponent/multitarget low dose medication that can be introduced in the patient's therapeutic plan in overlapping with Proton Pump Inhibitors (PPIs) to progressively reduce the use of PPIs through an appropriate decalage plan. All the statements were approved with a large majority by a panel of gastroenterologists, otolaryngologists, geriatrics, and general practitioners expert in GERD, demonstrating their validity and the importance of the topic covered by the consensus.
Publish Date	2024-05-11 10:58
Citation	<p>Battaglia E, Bertolusso L, Del Prete M, Monzani M, Astegiano M. Overlapping approach PPIs/Nux vomica-Heel as new intervention model in the management of GERD: A Delphi consensus study. <i>World J Gastroenterol</i> 2024; 30(18): 2467-2478</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i18/2467.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i18.2467

Full Article (PDF)	WJG-30-2467-with-cover.pdf
Manuscript File	92303_Auto_Edited-YJP-v2.docx
Answering Reviewers	92303-Answering reviewers.pdf
Audio Core Tip	92303-Audio core tip.mp3
Biostatistics Review Certificate	92303-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92303-Conflict-of-interest statement.pdf
Copyright License Agreement	92303-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92303-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	92303-Language certificate.pdf
Peer-review Report	92303-Peer-review(s).pdf
Scientific Misconduct Check	92303-Bing-Li L-2.png
Scientific Editor Work List	92303-Scientific editor work list.pdf
CrossCheck Report	92303-CrossCheck.png
CrossCheck Report	92303-CrossCheck report.pdf