Publication Name	World Journal of Clinical Cases
Manuscript ID	92311
Country	China

Received	2024-01-25 15:00
Peer-Review Started	2024-01-25 15:00
To Make the First Decision
Return for Revision	2024-02-28 05:56
Revised	2024-03-10 08:47
Second Decision	2024-04-09 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-09 07:53
Articles in Press	2024-04-09 07:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-08 06:58
Publish the Manuscript Online	2024-05-14 08:48

ISSN	2307-8960 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Case Report
Article Title	C634Y mutation in RET-induced multiple endocrine neoplasia type 2A: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Fen Zhang, Shu-Ling Huang, Wen-Li Wang, Yu-Qing Zhou, Jun Jiang and Zhuo-Jin Dai
ORCID	Author(s) ORCID Number Hui-Fen Zhang http://orcid.org/0009-0009-9103-4129 Shu-Ling Huang http://orcid.org/0000-0002-6082-0014 Wen-Li Wang http://orcid.org/0009-0008-5446-2813 Yu-Qing Zhou http://orcid.org/0000-0002-2011-6372 Jun Jiang http://orcid.org/0000-0002-7119-2682 Zhuo-Jin Dai http://orcid.org/0000-0003-1047-2549
Funding Agency and Grant Number	Funding Agency Grant Number The Finance Bureau of Dongguan City, Guangdong Province
Corresponding Author	Yu-Qing Zhou, MMed, Chief, Professor, Department of Endocrinology, Dongguan Hospital of Guangzhou University of Chinese Medicine, No. 3 Dongcheng Section, Songshanhu Avenue, Dongcheng District, Dongguan 523003, Guangdong Province, China. 1411396541@qq.com
Key Words	Multiple endocrine neoplasia type 2A; Mutation; RET proto-oncogene; Medullary thyroid carcinoma; Pheochromocytoma; Case report
Core Tip	Gene sequencing was performed on an adult Asian female patient with bilateral pheochromocytoma and thyroid carcinoma. A mutation, characterized by a nucleotide (c.T1901A) and amino acid (p.Cys634Tyr) change, was identified, supporting multiple endocrine neoplasia type 2A development. Genetic screening of family members revealed the patient’s father and son are carriers of the mutation. Clinical follow-up direction and treatment plan were guided by genetic testing. The patient and her son were diagnosed with orthotopic medullary thyroid carcinoma, facilitating timely and early detection in the early stage of cancer and potentially improving the survival rate of patients.
Publish Date	2024-05-14 08:48
Citation	<p>Zhang HF, Huang SL, Wang WL, Zhou YQ, Jiang J, Dai ZJ. C634Y mutation in RET-induced multiple endocrine neoplasia type 2A: A case report. <i>World J Clin Cases</i> 2024; 12(15): 2627-2635</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i15/2627.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i15.2627

Full Article (PDF)	WJCC-12-2627-with-cover.pdf
CARE Checklist–2016	92311-CARE Checklist (2016).pdf
Manuscript File	92311_Auto_Edited-YJP.docx
Answering Reviewers	92311-Answering reviewers.pdf
Audio Core Tip	92311-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	92311-Conflict-of-interest statement.pdf
Copyright License Agreement	92311-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92311-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	92311-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	92311-Language certificate.pdf
Peer-review Report	92311-Peer-review(s).pdf
Scientific Misconduct Check	92311-Bing-Che XX-2.png
Scientific Editor Work List	92311-Scientific editor work list.pdf
CrossCheck Report	92311-CrossCheck report.pdf