| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Development of a diagnostic nomogram for alpha-fetoprotein-negative hepatocellular carcinoma based on serological biomarkers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li He, Cui Zhang, Lan-Lan Liu, Li-Ping Huang, Wen-Jing Lu, Yuan-Yuan Zhang, De-Yong Zou, Yu-Fei Wang, Qing Zhang and Xiao-Li Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81972696 |
|
| Corresponding Author |
Xiao-Li Yang, DPhil, Chief Technician, Department of Laboratory Medicine, The Third Medical Centre of Chinese PLA General Hospital, No. 69 Yongding Road, Haidian District, Beijing 100039, China. yangxiaolitwins@163.com |
| Key Words |
Hepatocellular carcinoma; Alpha-fetoprotein-negative; Diagnostic; Nomogram; Biomarker |
| Core Tip |
The primary objective of this study was to develop a diagnostic model that can effectively identify patients with alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) using biomarkers. While previous research has demonstrated the usefulness of combining serological markers for diagnosing HCC, there have been limited investigations on diagnostic models specifically for AFP-negative HCC. Clinicians currently face the challenge of identifying individuals at high risk for early HCC, especially when patients exhibit normal levels of AFP. Early detection plays a crucial role in enabling timely surgical interventions, improving treatment outcomes, and ultimately enhancing the chances of survival for patients with HCC. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
He L, Zhang C, Liu LL, Huang LP, Lu WJ, Zhang YY, Zou DY, Wang YF, Zhang Q, Yang XL. Development of a diagnostic nomogram for alpha-fetoprotein-negative hepatocellular carcinoma based on serological biomarkers. World J Gastrointest Oncol 2024; 16(6): 2463-2475 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2463.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2463 |
