Publication Name	World Journal of Stem Cells
Manuscript ID	92363
Country	China

Received	2024-01-23 13:59
Peer-Review Started	2024-01-23 13:59
To Make the First Decision
Return for Revision	2024-03-09 06:15
Revised	2024-03-23 03:51
Second Decision	2024-04-15 10:05
Accepted by Journal Editor-in-Chief	2024-04-18 04:47
Accepted by Executive Editor-in-Chief	2024-04-22 06:28
Articles in Press	2024-04-22 06:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-18 05:46
Publish the Manuscript Online	2024-06-25 10:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Obstetrics & Gynecology
Manuscript Type	Basic Study
Article Title	Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
Manuscript Source	Unsolicited Manuscript
All Author List	Lei-Mei Xu, Xin-Xin Yu, Ning Zhang and Yi-Song Chen
ORCID	Author(s) ORCID Number Yi-Song Chen http://orcid.org/0000-0002-9234-8893
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81671439 Science and Technology Commission of Shanghai Municipality 21Y11906700, 20Y11907300 Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality 22Y11906500
Corresponding Author	Yi-Song Chen, Doctor, Chief Doctor, Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, No. 128 Shenyang Road, Shanghai 200011, China. cys373900207@163.com
Key Words	Pelvic organ prolapse; Exosomes; Fibroblasts; Human umbilical cord mesenchymal stromal cells; Extracellular matrix; Collagen I
Core Tip	Our original article, titled “Exosomes derived from hucMSCs promote the growth and collagen production of fibroblasts from pelvic organ prolapse through microRNAs” focused on a promising cell-free treatment for pelvic organ prolapse (POP). Our study the first demonstrated that human umbilical cord mesenchymal stromal cell-derived exosome (hucMSC-Exo) at certain concentrations could facilitate the growth and extracellular matrix remodeling of the primary fibroblasts from POP. Morever, microRNA sequencing of hucMSC-Exos and high-throughput RNA sequencing of fibroblasts exposed to hucMSC-Exos revealed that highly expressed exosomal microRNAs targeted and downregulated the expression of matrix metalloproteinase 11 in fibroblasts, leading to the increased production of collagen I. These results suggested that hucMSC-Exos could be a promising treatment for POP and may overcome current therapeutic difficulties.
Publish Date	2024-06-25 10:11
Citation	<p>Xu LM, Yu XX, Zhang N, Chen YS. Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse. <i>World J Stem Cells</i> 2024; 16(6): 708-727</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i6/708.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i6.708

Full Article (PDF)	WJSC-16-708-with-cover.pdf
Manuscript File	92363_Auto_Edited-YJP.docx
Answering Reviewers	92363-answering-reviewers.pdf
Audio Core Tip	92363-audio.m4a
Biostatistics Review Certificate	92363-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	92363-conflict-of-interest-statement.pdf
Copyright License Agreement	92363-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92363-foundation-statement.pdf
Institutional Review Board Approval Form or Document	92363-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	92363-non-native-speakers.pdf
Video	92363-Video.zip
Supplementary Material	92363-supplementary-material.pdf
Peer-review Report	92363-peer-reviews.pdf
Journal Editor-in-Chief Review Report	92363-journal-editor-in-chief.pdf
Scientific Misconduct Check	92363-scientific-misconduct-check.png
Scientific Editor Work List	92363-scientific-editor-work-list.pdf
CrossCheck Report	92363-crosscheck-report.pdf