| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Hemolysis attributed to high dose vitamin C: Two case reports
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Wan Wang, Xiao-Wei Zhang, Jin-Xiu Qu, Yi-Zhong Rao, Shuai LU, Bing Wang, Jia He, Yuan Zhao and Ben-Qiang Rao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
82074061 |
| The National Key Research and Development Program of China |
2022YFC2009600 |
|
| Corresponding Author |
Ben-Qiang Rao, Doctor, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Surgeon, Center for Oncology Nutrition and Metabolism, Beijing Shijitan Hospital, Capital Medical University/Key Laboratory of Cancer FSMP for State Market Regulation, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing 100038, China. raobenqiang@bjsjth.cn |
| Key Words |
Hemolysis; Vitamin C; Adverse effects; Acute kidney injury; Cancer; Case report |
| Core Tip |
Two patients suffered from extremely severe hemolysis after high dose vitamin C treatment (HVCT), and both patients had glucose-6-phosphatase dehydrogenase (G6PD) deficiency. By reviewing the literature and summarizing the findings of available case reports, we conclude for the first time that patients who develop hemolytic anemia after HVCT may have G6PD deficiency, thus G6PD deficiency is an absolute contraindication for HVCT. Our treatment protected the patients from acute kidney injury in the context of extremely severe hemolysis. Our experience may be helpful for the treatment of similar cases. |
| Publish Date |
2024-06-04 15:55 |
| Citation |
<p>Wang SW, Zhang XW, Qu JX, Rao YZ, LU S, Wang B, He J, Zhao Y, Rao BQ. Hemolysis attributed to high dose vitamin C: Two case reports. <i>World J Clin Cases</i> 2024; 12(17): 3168-3176</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i17/3168.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i17.3168 |
