Publication Name	World Journal of Stem Cells
Manuscript ID	92406
Country	China

Received	2024-01-25 04:14
Peer-Review Started	2024-01-25 04:14
To Make the First Decision
Return for Revision	2024-06-05 03:15
Revised	2024-07-24 14:49
Second Decision	2024-09-24 08:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-12 08:20
Articles in Press	2024-10-12 08:20
Publication Fee Transferred	2024-10-17 02:35
Edit the Manuscript by Language Editor	2024-10-23 08:27
Typeset the Manuscript	2024-10-30 12:43
Publish the Manuscript Online	2024-11-26 10:21

ISSN	1948-0210 (online)
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Category	Anatomy & Morphology
Manuscript Type	Basic Study
Article Title	Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Yu Zhang, Han-Bi Wang and Cheng-Yan Deng
ORCID	Author(s) ORCID Number Wan-Yu Zhang http://orcid.org/0000-0002-3411-1492 Cheng-Yan Deng http://orcid.org/0000-0001-6832-7307
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding 2022-PUMCH-B-080, 2022-PUMCH-C-064
Corresponding Author	Cheng-Yan Deng, MD, PhD, Doctor, Doctor, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. chydmd@sohu.com
Key Words	Endometrial epithelial cells; Exosomes; Human umbilical cord mesenchymal stem cells; MiR-214-5p/miR-21-5p; Signal transducer and activator of transcription 3
Core Tip	Thin endometrium is a primary cause of repeated implantation failure and infertility. In this manuscript, with the help of microRNA sequence, we investigated the role of hypoxic endometrial epithelial cell (EEC)-derived exosomes in cell function of human umbilical cord mesenchymal stem cells and explore the potential mechanism. Eventually, we found lowly-expressed miR-21-5p and miR-214-5p in hypoxic EEC-derived exosomes promoted migration and differentiation into EECs of human umbilical cord mesenchymal stem cells via signal transducer and activator of transcription 3 signaling. Exosomal miR-214-5p and miR-21-5p may function as valuable targets for thin endometrium.
Publish Date	2024-11-26 10:21
Citation	<p>Zhang WY, Wang HB, Deng CY. Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. <i>World J Stem Cells</i> 2024; 16(11): 906-925</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i11/906.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i11.906

Full Article (PDF)	WJSC-16-906-with-cover.pdf
Manuscript File	92406_Auto_Edited_055311.docx
Answering Reviewers	92406-answering-reviewers.pdf
Audio Core Tip	92406-audio.m4a
Biostatistics Review Certificate	92406-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	92406-conflict-of-interest-statement.pdf
Copyright License Agreement	92406-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92406-foundation-statement.pdf
Institutional Review Board Approval Form or Document	92406-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	92406-non-native-speakers.pdf
Supplementary Material	92406-supplementary-material.pdf
Peer-review Report	92406-peer-reviews.pdf
Scientific Misconduct Check	92406-scientific-misconduct-check.png
Scientific Editor Work List	92406-scientific-editor-work-list.pdf
CrossCheck Report	92406-crosscheck-report.pdf