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Articles Published Processes
11/26/2024 10:21:34 AM | Browse: 231 | Download: 862
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Received |
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2024-01-25 04:14 |
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Peer-Review Started |
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2024-01-25 04:14 |
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First Decision by Editorial Office Director |
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2024-06-05 03:15 |
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Return for Revision |
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2024-06-05 03:15 |
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Revised |
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2024-07-24 14:49 |
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Publication Fee Transferred |
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2024-10-17 02:35 |
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Second Decision by Editor |
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2024-09-24 08:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-12 08:20 |
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Articles in Press |
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2024-10-12 08:20 |
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Edit the Manuscript by Language Editor |
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2024-10-23 08:27 |
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Typeset the Manuscript |
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2024-10-30 12:43 |
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Publish the Manuscript Online |
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2024-11-26 10:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anatomy & Morphology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Yu Zhang, Han-Bi Wang and Cheng-Yan Deng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
2022-PUMCH-B-080, 2022-PUMCH-C-064 |
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| Corresponding Author |
Cheng-Yan Deng, MD, PhD, Doctor, Doctor, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. chydmd@sohu.com |
| Key Words |
Endometrial epithelial cells; Exosomes; Human umbilical cord mesenchymal stem cells; MiR-214-5p/miR-21-5p; Signal transducer and activator of transcription 3 |
| Core Tip |
Thin endometrium is a primary cause of repeated implantation failure and infertility. In this manuscript, with the help of microRNA sequence, we investigated the role of hypoxic endometrial epithelial cell (EEC)-derived exosomes in cell function of human umbilical cord mesenchymal stem cells and explore the potential mechanism. Eventually, we found lowly-expressed miR-21-5p and miR-214-5p in hypoxic EEC-derived exosomes promoted migration and differentiation into EECs of human umbilical cord mesenchymal stem cells via signal transducer and activator of transcription 3 signaling. Exosomal miR-214-5p and miR-21-5p may function as valuable targets for thin endometrium. |
| Publish Date |
2024-11-26 10:21 |
| Citation |
Zhang WY, Wang HB, Deng CY. Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. World J Stem Cells 2024; 16(11): 906-925
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| URL |
https://www.wjgnet.com/1948-0210/full/v16/i11/906.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i11.906 |
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