Publication Name	World Journal of Hepatology
Manuscript ID	92426
Country	Germany

Received	2024-01-25 14:43
Peer-Review Started	2024-01-26 00:52
To Make the First Decision
Return for Revision	2024-06-16 19:48
Revised	2024-06-30 07:03
Second Decision	2024-07-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-09 08:43
Articles in Press	2024-07-09 08:43
Publication Fee Transferred	2025-03-04 16:39
Edit the Manuscript by Language Editor	2025-03-26 04:28
Typeset the Manuscript	2025-04-18 01:02
Publish the Manuscript Online	2025-04-25 08:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Stephan Drexler, Frederic Haedge, Susanne N Weber, Marcin Krawczyk, Matthias S Matter, Carol I Geppert, Achim Weber, Bruno Stieger, Christian Trautwein and Andreas E Kremer
ORCID	Author(s) ORCID Number Stephan Drexler http://orcid.org/0000-0002-0970-5088
Funding Agency and Grant Number
Corresponding Author	Stephan Drexler, MD, Doctor, Doctor, Department of Medicine III, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Aachen 52070, Germany. sdrexler@ukaachen.de
Key Words	Intrahepatic cholestasis; Hepatitis E; Next generation sequencing; ATP8B1; Case report
Core Tip	This case report highlights the role of genetic variations in hepatobiliary transporters in predisposing individuals to intrahepatic cholestasis and identifies hepatitis E virus (HEV) as a potential trigger. We present two cases of HEV-triggered intrahepatic cholestasis in patients with polymorphisms in ATP8B1 and other transporter genes. These findings suggest that these genetic variants may be susceptibility factors for cholestatic episodes, underscoring the need for further research to confirm these results in larger patient cohorts and through functional studies.
Publish Date	2025-04-25 08:23
Citation	<p>Drexler S, Haedge F, Weber SN, Krawczyk M, Matter MS, Geppert CI, Weber A, Stieger B, Trautwein C, Kremer AE. Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report. <i>World J Hepatol</i> 2025; 17(4): 92426</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i4/92426.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i4.92426

Full Article (PDF)	WJH-17-92426-with-cover.pdf
CARE Checklist–2016	92426-CARE-Checklist-2016.pdf
Manuscript File	92426_Auto_Edited_062241.docx
Answering Reviewers	92426-answering-reviewers.pdf
Audio Core Tip	92426-audio.mp3
Conflict-of-Interest Disclosure Form	92426-conflict-of-interest-statement.pdf
Copyright License Agreement	92426-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	92426-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	92426-non-native-speakers.pdf
Supplementary Material	92426-supplementary-material.pdf
Peer-review Report	92426-peer-reviews.pdf
Scientific Misconduct Check	92426-scientific-misconduct-check.png
Scientific Editor Work List	92426-scientific-editor-work-list.pdf
CrossCheck Report	92426-crosscheck-report.png
CrossCheck Report	92426-crosscheck-report.pdf