Publication Name	World Journal of Stem Cells
Manuscript ID	92572
Country	China

Received	2024-01-30 04:03
Peer-Review Started	2024-01-30 04:03
To Make the First Decision
Return for Revision	2024-02-07 06:16
Revised	2024-02-20 08:17
Second Decision	2024-03-21 02:51
Accepted by Journal Editor-in-Chief	2024-03-24 05:47
Accepted by Executive Editor-in-Chief	2024-04-02 03:10
Articles in Press	2024-04-02 03:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-04-06 22:59
Typeset the Manuscript	2024-05-13 09:18
Publish the Manuscript Online	2024-05-24 08:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Bo Wang, Ming-Wei Du and Yan Zheng
ORCID	Author(s) ORCID Number Yan Zheng http://orcid.org/0009-0007-5741-7543
Funding Agency and Grant Number	Funding Agency Grant Number Hangzhou Municipal Bureau of Science and Technology 2021WJCY366
Corresponding Author	Yan Zheng, MMed, Staff Physician, Department of Hepatic, The Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese Medicine, No. 2 Hengbu Street, Liuliu Town, Xihu District, Hangzhou 310023, Zhejiang Province, China. zjhzzygood@163.com
Key Words	Aplastic anemia; Ginsenoside Rg1; Myelosuppression; MAPK signaling pathway; Bone marrow; Hematopoietic stem cells
Core Tip	This study evaluates ginsenoside Rg1’s efficacy in aplastic anemia (AA) treatment, focusing on its impact on bone marrow pathology, hematopoiesis, and inflammation in a cyclophosphamide-induced myelosuppression C57 mice model. It demonstrates that ginsenoside Rg1 not only reduces cell apoptosis and inflammation but also promotes hematopoietic recovery by inhibiting the MAPK signaling pathway, offering a potential therapeutic strategy for AA.
Publish Date	2024-05-24 08:33
Citation	<p>Wang JB, Du MW, Zheng Y. Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway. <i>World J Stem Cells</i> 2024; 16(5): 591-603</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i5/591.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i5.591

Full Article (PDF)	WJSC-16-591-with-cover.pdf
Full Article (Word)	WJSC-16-591.docx
The ARRIVE Guidelines	92572-The ARRIVE guidelines.pdf
Manuscript File	92572-Review-FilipodiaCL.docx
Answering Reviewers	92572-Answering reviewers.pdf
Audio Core Tip	92572-Audio core tip.mp3
Biostatistics Review Certificate	92572-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92572-Conflict-of-interest statement.pdf
Copyright License Agreement	92572-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92572-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	92572-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	92572-Language certificate.pdf
Peer-review Report	92572-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	92572-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	92572-Bing-Wang JJ-2.png
Scientific Editor Work List	92572-Scientific editor work list.pdf
CrossCheck Report	92572-CrossCheck report.pdf