Publication Name	World Journal of Gastroenterology
Manuscript ID	92587
Country	China

Received	2024-01-30 13:31
Peer-Review Started	2024-01-30 13:31
To Make the First Decision
Return for Revision	2024-03-07 05:26
Revised	2024-04-05 05:43
Second Decision	2024-04-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-18 03:15
Articles in Press	2024-04-18 03:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-08 08:11
Publish the Manuscript Online	2024-05-20 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Fei Li, Fang-Yuan Zheng, Xin-Yu Miao, Hai-Long Liu, Yao-Yao Zhang, Nai-Xia Chao and Fa-Rong Mo
ORCID	Author(s) ORCID Number Yan-Fei Li http://orcid.org/0000-0002-1533-7373 Nai-Xia Chao http://orcid.org/0000-0001-9470-4954 Fa-Rong Mo http://orcid.org/0000-0003-2564-7460
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Guangxi Zhuang Autonomous Region, China No. 2023GXNSFAA026070 and No. 2018GXNSFAA281071
Corresponding Author	Fa-Rong Mo, MD, Professor, School of Basic Medical Sciences, Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. farongmo@126.com
Key Words	Apoptosis; Proliferation; Endoplasmic reticulum stress; Hepatocellular carcinoma; Cell division cyclin 25C
Core Tip	In the current study, cell division cyclin 25C (CDC25C) is an important cell cycle regulatory protein and a potential target for cancer treatment. CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the endoplasmic reticulum (ER) stress response. Furthermore, CDC25C knockdown promoted ER stress-induced apoptosis in hepatocellular carcinoma (HCC) cells. The regulatory mechanism of CDC25C in HCC development might be related to the activation of ER stress and the ER stress-induced apoptosis signaling pathway.
Publish Date	2024-05-20 09:15
Citation	<p>Li YF, Zheng FY, Miao XY, Liu HL, Zhang YY, Chao NX, Mo FR. Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress. <i>World J Gastroenterol</i> 2024; 30(19): 2564-2574</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i19/2564.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i19.2564

Full Article (PDF)	WJG-30-2564-with-cover.pdf
The ARRIVE Guidelines	92587-The ARRIVE guidelines.pdf
Manuscript File	92587_Auto_Edited-YJP.docx
Answering Reviewers	92587-Answering reviewers.pdf
Audio Core Tip	92587-Audio core tip.mp3
Biostatistics Review Certificate	92587-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92587-Conflict-of-interest statement.pdf
Copyright License Agreement	92587-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92587-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	92587-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	92587-Language certificate.pdf
Peer-review Report	92587-Peer-review(s).pdf
Scientific Misconduct Check	92587-Bing-Qu XL-2.jpg
Scientific Editor Work List	92587-Scientific editor work list.pdf
CrossCheck Report	92587-CrossCheck report.pdf