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Articles Published Processes
5/20/2024 9:15:31 AM | Browse: 167 | Download: 880
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Received |
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2024-01-30 13:31 |
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Peer-Review Started |
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2024-01-30 13:31 |
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First Decision by Editorial Office Director |
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2024-03-07 05:26 |
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Return for Revision |
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2024-03-07 05:26 |
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Revised |
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2024-04-05 05:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-04-18 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-04-18 03:15 |
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Articles in Press |
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2024-04-18 03:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-08 08:11 |
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Publish the Manuscript Online |
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2024-05-20 09:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Fei Li, Fang-Yuan Zheng, Xin-Yu Miao, Hai-Long Liu, Yao-Yao Zhang, Nai-Xia Chao and Fa-Rong Mo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangxi Zhuang Autonomous Region, China |
No. 2023GXNSFAA026070 and No. 2018GXNSFAA281071 |
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| Corresponding Author |
Fa-Rong Mo, MD, Professor, School of Basic Medical Sciences, Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. farongmo@126.com |
| Key Words |
Cell division cyclin 25C; Hepatocellular carcinoma; Endoplasmic reticulum stress; Proliferation; Apoptosis |
| Core Tip |
In the current study, cell division cyclin 25C (CDC25C) is an important cell cycle regulatory protein and a potential target for cancer treatment. CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the endoplasmic reticulum (ER) stress response. Furthermore, CDC25C knockdown promoted ER stress-induced apoptosis in hepatocellular carcinoma (HCC) cells. The regulatory mechanism of CDC25C in HCC development might be related to the activation of ER stress and the ER stress-induced apoptosis signaling pathway. |
| Publish Date |
2024-05-20 09:15 |
| Citation |
Li YF, Zheng FY, Miao XY, Liu HL, Zhang YY, Chao NX, Mo FR. Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress. World J Gastroenterol 2024; 30(19): 2564-2574 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i19/2564.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i19.2564 |
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