Publication Name	World Journal of Experimental Medicine
Manuscript ID	92589
Country	Sweden

Received	2024-01-31 13:27
Peer-Review Started	2024-01-31 13:27
To Make the First Decision
Return for Revision	2024-06-07 19:50
Revised	2024-06-19 11:40
Second Decision	2024-07-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-10 08:44
Articles in Press	2024-07-10 08:44
Publication Fee Transferred	2024-07-31 07:28
Edit the Manuscript by Language Editor	2024-08-14 16:10
Typeset the Manuscript	2024-08-22 03:56
Publish the Manuscript Online	2024-08-29 06:31

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions
Manuscript Source	Unsolicited Manuscript
All Author List	Kateryna Pierzynowska, Piotr Wychowanski, Kamil Zaworski, Jarosław Woliński, Janine Donaldson, Dominika Szkopek, Katarzyna Roszkowicz-Ostrowska, Agata Kondej and Stefan G Pierzynowski
ORCID	Author(s) ORCID Number Kateryna Pierzynowska http://orcid.org/0000-0002-3290-339X Piotr Wychowanski http://orcid.org/0000-0002-6286-5697 Jarosław Woliński http://orcid.org/0000-0001-8645-1045 Stefan G Pierzynowski http://orcid.org/0000-0002-0308-3214
Funding Agency and Grant Number
Corresponding Author	Kateryna Pierzynowska, DSc, PhD, Associate Professor, Senior Research Fellow, Department of Biology, Lund University, Sölvegatan 35, Lund 22362, Sweden. kateryna.pierzynowska@biol.lu.se
Key Words	Amylase; Glucose-insulin-amylase interaction; Intravenous glucose tolerance test; Acini-islet-acinar axis; Insulin
Core Tip	The acini-islet-acinar axis involves the inhibition of insulin production by amylase and the stimulation of amylase release by insulin, which is of particular significance with regards to glucose regulation. There is increasing evidence that amylase levels correspond to overall metabolic health, with low amylase levels being significantly associated with the development of metabolic syndrome, diabetes, and obesity. Disruption of the highly integrated glucose-insulin interactions by intrapancreatic arterial amylase infusion in the present study confirms the existence of an AIA reflex and justifies the placement of the exocrine and endocrine pancreatic components within the same organ.
Publish Date	2024-08-29 06:31
Citation	<p>Pierzynowska K, Wychowanski P, Zaworski K, Woliński J, Donaldson J, Szkopek D, Roszkowicz-Ostrowska K, Kondej A, Pierzynowski SG. Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions. <i>World J Exp Med</i> 2024; 14(3): 92589</p>
URL	https://www.wjgnet.com/2220-315x/full/v14/i3/92589.htm
DOI	https://dx.doi.org/10.5493/wjem.v14.i3.92589

Full Article (PDF)	WJEM-14-92589-with-cover.pdf
The ARRIVE Guidelines	92589-The-ARRIVE-Guidelines.pdf
Manuscript File	92589_Auto_Edited_005627.docx
Answering Reviewers	92589-answering-reviewers.pdf
Audio Core Tip	92589-audio.m4a
Biostatistics Review Certificate	92589-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	92589-conflict-of-interest-statement.pdf
Copyright License Agreement	92589-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	92589-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	92589-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	92589-non-native-speakers.pdf
Peer-review Report	92589-peer-reviews.pdf
Scientific Misconduct Check	92589-scientific-misconduct-check.png
Scientific Editor Work List	92589-scientific-editor-work-list.pdf
CrossCheck Report	92589-crosscheck-report.pdf