| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai-Di Chen, Kui-Ling Wang, Chen Chen, Yi-Jia Zhu, Wen-Wen Tang, Yu-Ji Wang, Ze-Peng Chen, Lin-Hai He, Yu-Gen Chen and Wei Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82374449 |
| China Postdoctoral Science Foundation |
2023M731782 |
| Jiangsu Funding Program for Excellent Postdoctoral Talent |
2022ZB806 |
| Jiangsu Province Postgraduate Scientific Research and Innovation Plan |
KYCX23_2136 |
|
| Corresponding Author |
Yu-Gen Chen, MD, PhD, Chief Doctor, Professor, Department of Colorectal Surgery, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210029, Jiangsu Province, China. yugen.chen@njucm.edu.cn |
| Key Words |
Hydrogen-rich water; Constipation; Sirtuin1; Oxidative stress; Gut microbiota; Serum metabolites |
| Core Tip |
Constipation is a highly prevalent functional gastrointestinal disorder. Identifying cost-effective and efficient therapeutic modalities for constipation is of paramount importance. In the present study, hydrogen-rich water alleviated constipation by attenuating intestinal oxidative stress through the sirtuin1 (SIRT1)/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway and modulating gut microbiota and serum metabolites. β-leucine and traumatic acid were identified as potential metabolites for the treatment of constipation, inducing increased SIRT1 expression and decreased oxidative stress. |
| Publish Date |
2024-05-27 09:35 |
| Citation |
<p>Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W. Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway. <i>World J Gastroenterol</i> 2024; 30(20): 2709-2725</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i20/2709.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i20.2709 |
