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12/2/2015 12:22:00 PM | Browse: 838 | Download: 616
Publication Name World Journal of Hepatology
Manuscript ID 9278
Country/Territory Turkey
Received
2014-01-29 22:24
Peer-Review Started
2014-02-08 09:36
To Make the First Decision
2014-02-27 10:32
Return for Revision
2014-03-11 21:19
Revised
2014-03-13 17:47
Second Decision
2014-07-14 17:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-14 17:13
Articles in Press
2014-07-14 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-22 15:55
Typeset the Manuscript
2014-08-28 14:03
Publish the Manuscript Online
2014-08-29 07:54
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Circulating microRNAs in patients with non-alcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Mehmet Celikbilek, Mevlut Baskol, Serpil Taheri, Kemal Deniz, Serkan Dogan, Gokmen Zararsız, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Munis Dundar and Mehmet Yucesoy
Funding Agency and Grant Number
Corresponding author Mehmet Celikbilek, MD, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey. drcelikbilek@yahoo.com
Keywords Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; MicroRNA; Noninvasive; Serum markers
Core Tip Due to the limitations of liver biopsy, the use of non-invasive markers has emerged in recent years. MicroRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs that regulate gene expression. Altered miRNA expression has been reported in animal and human liver samples in non-alcoholic fatty liver disease (NAFLD). There is, however, only limited information on their detection in blood and their correlation with histological disease severity in patients with NAFLD. For this reason, we measured the serum levels of some miRNAs in non-alcoholic steatohepatitis (NASH) patients. Of these microRNAs, miR-181d, miR-99a, miR-197 and miR-146b were expressed at lower levels in NASH patients than in controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in NASH patients.
Publish Date 2014-08-29 07:54
Citation Celikbilek M, Baskol M, Taheri S, Deniz K, Dogan S, Zararsız G, Gursoy S, Guven K, Ozbakır O, Dundar M, Yucesoy M. Circulating microRNAs in patients with non-alcoholic fatty liver disease. World J Hepatol 2014; 6(8): 613-620
Url http://www.wjgnet.com/1948-5182/full/v6/i8/613.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i8.613
Full Article (PDF) WJH-6-613.pdf
Full Article (Word) WJH-6-613.doc
Manuscript File 9278-Review.doc
Answering Reviewers 9278-Answering reviewers.pdf
Copyright License Agreement 9278-Copyright assignment.pdf
Peer-review Report 9278-Peer review(s).pdf
Scientific Misconduct Check 9278-CrossCheck.jpg
Scientific Editor Work List 9278-Scientific editor work list.pdf