Publication Name	World Journal of Gastroenterology
Manuscript ID	92793
Country	Mexico

Received	2024-02-05 20:24
Peer-Review Started	2024-02-05 20:24
To Make the First Decision
Return for Revision	2024-03-02 07:14
Revised	2024-03-08 01:16
Second Decision	2024-04-16 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-16 05:45
Articles in Press	2024-04-16 05:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-29 16:53
Publish the Manuscript Online	2024-05-11 10:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Navigating the controversy regarding antibiotic prophylaxis in acute variceal bleeding
Manuscript Source	Unsolicited Manuscript
All Author List	David Aguirre-Villarreal and Ignacio García-Juárez
ORCID	Author(s) ORCID Number David Aguirre-Villarreal http://orcid.org/0000-0001-8277-6846 Ignacio García-Juárez http://orcid.org/0000-0003-2400-1887
Funding Agency and Grant Number
Corresponding Author	Ignacio García-Juárez, MD, Professor, Department of Gastroenterology and Liver Transplant Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Domínguez Secc 16, Tlalpan, Mexico City 14080, Mexico. ignacio.garciaj@incmnsz.mx
Key Words	Cirrhosis; Acute variceal bleeding; Antibiotic prophylaxis; Endoscopic band ligation; Spontaneous bacterial peritonitis
Core Tip	Although antibiotic prophylaxis is currently a part of guideline-directed therapy for patients with cirrhosis and acute variceal bleeding, new and conflicting evidence has challenged this premise. While previous meta-analyses supported prophylaxis, a recent retrospective cohort study by Ichita et al regarding acute esophageal variceal bleeding found no significant differences in mortality, rebleeding, or bacterial peritonitis between prophylaxis and non-prophylaxis groups. A tailored approach that considers underlying liver function, the method of endoscopic treatment, and local antibiotic resistance patterns might be more appropriate.
Publish Date	2024-05-11 10:58
Citation	<p>Aguirre-Villarreal D, García-Juárez I. Navigating the controversy regarding antibiotic prophylaxis in acute variceal bleeding. <i>World J Gastroenterol</i> 2024; 30(18): 2485-2487</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i18/2485.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i18.2485

Full Article (PDF)	WJG-30-2485-with-cover.pdf
Manuscript File	92793_Auto_Edited-YJP.docx
Answering Reviewers	92793-Answering reviewers.pdf
Audio Core Tip	92793-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	92793-Conflict-of-interest statement.pdf
Copyright License Agreement	92793-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	92793-Language certificate.pdf
Peer-review Report	92793-Peer-review(s).pdf
Scientific Misconduct Check	92793-Bing-Li L-2.png
Scientific Editor Work List	92793-Scientific editor work list.pdf
CrossCheck Report	92793-CrossCheck.png
CrossCheck Report	92793-CrossCheck report.pdf