| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yasuhiko Saeki, Jun Sawaguchi, Satori Akita, Taka-aki Takamura, Kosuke Fujibayashi, Minoru Wakasa, Hironobu Akao, Michihiko Kitayama, Yasuyuki Kawai and Kouji Kajinami |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Vehicle Racing Commemorative Foundation |
2013-2015 |
| Grant-in-aid for Scientific Research (C) |
18K08051 |
| Grant-in-Aid for Scientific Research (C) |
21K08139 |
| Collaborative Research from Kanazawa Medical Univesrity |
C2015-4 |
|
| Corresponding Author |
Kouji Kajinami, FACP, FAHA, MD, Professor, Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada 9200293, Japan. kajinami@kanazawa-med.ac.jp |
| Key Words |
Lipoprotein (a); Acute coronary syndrome; Percutaneous coronary intervention; Major adverse cardiac events; Prognosis |
| Core Tip |
Two hundred and forty-nine patients with acute coronary syndrome were enrolled in the study. Lipoprotein(a) [Lp(a)] levels were measured before percutaneous coronary intervention (PCI) to 48 h after using an isoform-independent assay. Lp(a) levels decreased significantly from pre-PCI (0 h) to 12 h after, and then increased up to 48 h after. The changes from 0 to 12 h [Lp(a)Δ0-12] were significantly correlated with basal creatinine and Lp(a). Among the tertiles classified according to the changes from 0 to 12 h [Lp(a)Δ0-12], major adverse cardiac events (MACE) were significantly more frequent in the lowest Lp(a)Δ0-12 group than in the other two groups. Multivariate analysis revealed that Lp(a)Δ0-12 and basal creatinine were independent determinants of subsequent MACE. |
| Publish Date |
2024-06-25 10:25 |
| Citation |
<p>Saeki Y, Sawaguchi J, Akita S, Takamura TA, Fujibayashi K, Wakasa M, Akao H, Kitayama M, Kawai Y, Kajinami K. Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome. <i>World J Cardiol</i> 2024; 16(6): 329-338</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v16/i6/329.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v16.i6.329 |
