| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Li Yin, Ping-Qian Qi, Yun-Fei Hu, Xiao-Jun Fu, Rui-Shan He, Meng-Meng Wang, Yan-Juan Deng, Su-Yi Xiong, Qi-Wen Yu, Jin-Ping Hu, Lv Zhou, Zhi-Bin Zhou, Ying Xiong and Huan Deng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation of China |
82160546 |
| Science Foundation of Jiangxi Province |
20202BBG73027 |
| Foundation of Jiangxi Province for Distinguished Scholars |
jxsq2023201020 |
| Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine |
2022B789 |
|
| Corresponding Author |
Huan Deng, MD, PhD, Professor, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, No. 133 South Guangchang Road, Nanchang 330006, Jiangxi Province, China. beandeng@ncu.edu.cn |
| Key Words |
Dysbiosis; Biopsy; Polyp; Bacteria; Colorectum |
| Core Tip |
This study investigates the links between intestinal dysbiosis and recurrent colorectal polyps using 16S RNA sequencing. Findings reveal reduced probiotics and increased pathogenic bacteria in the mucosa surrounding or 10 cm distal to the polyps. Significant differences in bacterial diversity were found among normal mucosa, non-adenomous polyps, and adenomous polyps. Increased Gram-negative bacteria, such as Klebsiella, Plesiomonas, and Cronobacter, suggest that antibiotic resistance may contribute to the establishment of a harmful environment. Age and gender also influence bacterial changes, indicating the involvement of sex hormones. Targeting specific pathogenic bacteria may facilitate the prevention of recurrent polyps. |
| Publish Date |
2024-08-08 04:58 |
| Citation |
<p>Yin LL, Qi PQ, Hu YF, Fu XJ, He RS, Wang MM, Deng YJ, Xiong SY, Yu QW, Hu JP, Zhou L, Zhou ZB, Xiong Y, Deng H. Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum. <i>World J Gastrointest Oncol</i> 2024; 16(8): 3600-3623</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i8/3600.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i8.3600 |
