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Articles Published Processes
7/26/2024 6:56:09 AM | Browse: 239 | Download: 1056
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Received |
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2024-02-15 07:24 |
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Peer-Review Started |
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2024-02-15 07:25 |
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First Decision by Editorial Office Director |
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2024-04-23 06:06 |
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Return for Revision |
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2024-04-23 06:06 |
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Revised |
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2024-05-09 14:17 |
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Publication Fee Transferred |
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2024-06-19 01:54 |
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Second Decision by Editor |
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2024-06-11 06:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-06-18 08:44 |
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Articles in Press |
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2024-06-18 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-06-29 14:51 |
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Publish the Manuscript Online |
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2024-07-26 06:56 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Functional analysis of the novel mitochondrial tRNATrp and tRNASer(AGY) variants associated with type 2 diabetes mellitus
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Ding, Xue-Jiao Yu, Qin-Xian Guo and Jian-Hang Leng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China |
LHZY24H020002 |
| Hangzhou Municipal Health Commission |
ZD20220010 |
| Quzhou Bureau of Science and Technology |
2022K51 |
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| Corresponding Author |
Yu Ding, MD, Associate Professor, Central Laboratory, Hangzhou First People's Hospital, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. dingyu_zj@126.com |
| Key Words |
Type 2 diabetes mellitus; Mitochondrial tRNA genes; Novel variants; Oxidative stress; Mitochondrial dysfunctions |
| Core Tip |
We established cytoplasmic hybrid (cybrid) cells with m.A5514G and m.C12237T variants, and control cells without these variants. The m.A5514G variant decreased mt-tRNATrp stability, whereas the m.C12237T variant did not alter the stability of mt-tRNASer(AGY). More severe mitochondrial dysfunction was observed in mutant cybrids than in control cells, indicating that the m.A5514G variant impaired mt-tRNATrp metabolism and mitochondrial functions and increased cellular oxidative stress, which play central roles in type 2 diabetes mellitus (T2DM) progression. By contrast, the m.C12237T variant acted as a modifier of the m.A5514G variant. Our study provides novel insight into the pathophysiology of maternally transmitted T2DM caused by novel mt-tRNA variants. |
| Publish Date |
2024-07-26 06:56 |
| Citation |
Ding Y, Yu XJ, Guo QX, Leng JH. Functional analysis of the novel mitochondrial tRNATrp and tRNASer(AGY) variants associated with type 2 diabetes mellitus. World J Diabetes 2024; 15(8): 1753-1763 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i8/1753.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i8.1753 |
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