Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93008
Country	China

Received	2024-02-15 15:02
Peer-Review Started	2024-02-15 15:02
To Make the First Decision
Return for Revision	2024-09-01 22:46
Revised	2024-09-12 01:54
Second Decision	2024-09-20 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-20 06:34
Articles in Press	2024-09-20 06:34
Publication Fee Transferred	2024-09-20 14:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-11 05:45
Publish the Manuscript Online	2024-10-25 10:27

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yong-Gang He, Zheng Wang, Jing Li, Wang Xi, Chong-Yu Zhao, Xiao-Bing Huang and Lu Zheng
ORCID	Author(s) ORCID Number Xiao-Bing Huang http://orcid.org/0009-0002-3551-9665 Lu Zheng http://orcid.org/0000-0001-5714-6827
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Natural Science Foundation Project CSTB2022NSCQ-MSX0172 Incubation Project for Talented Young People 2022YQB031
Corresponding Author	Lu Zheng, Doctor, MD, PhD, Manager, Deputy Director, Doctor, Doctor, Professor, Department of Hepatobiliary, The Second Affiliated Hospital of Army Medical University, No. 183 Xinqiao High Street, Shapingba District, Chongqing 400037, China. zhenglu@tmmu.edu.cn
Key Words	Tumor organoids; Hepatocellular carcinoma; Drug sensitivity testing; Conversion therapy; Pathological response; Case report
Core Tip	Patient-derived tumor organoids have been demonstrated to improve the efficacy of conversion therapy by identifying individual-targeted effective drugs. Here we described a patient with hepatocellular carcinoma (HCC) who achieved pathologic complete response to conversion therapy guided by the patient-derived organoid (PDO) drug sensitivity testing. This typical case suggests that PDO-based drug sensitivity testing contributes to screening sensitive drugs for HCC patients to realize the personalized treatment and to improve the efficacy of conversion therapy, which may change the previous experiential therapy and serve as a novel treatment mode in liver cancer.
Publish Date	2024-10-25 10:27
Citation	<p>He YG, Wang Z, Li J, Xi W, Zhao CY, Huang XB, Zheng L. Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids: A case report. <i>World J Gastrointest Oncol</i> 2024; 16(11): 4506-4513</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i11/4506.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i11.4506

Full Article (PDF)	WJGO-16-4506-with-cover.pdf
CARE Checklist–2016	93008-CARE-Checklist-2016.pdf
Manuscript File	93008_Auto_Edited_092347.docx
Answering Reviewers	93008-answering-reviewers.pdf
Audio Core Tip	93008-audio.wav
Conflict-of-Interest Disclosure Form	93008-conflict-of-interest-statement.pdf
Copyright License Agreement	93008-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93008-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	93008-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	93008-non-native-speakers.pdf
Peer-review Report	93008-peer-reviews.pdf
Scientific Misconduct Check	93008-scientific-misconduct-check.png
Scientific Editor Work List	93008-scientific-editor-work-list.pdf
CrossCheck Report	93008-crosscheck-report.pdf