| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury through activating transcription factor 6 in diabetic nephropathy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jiang Liu, Xiao-Yun Song, Xiu-Ting Li, Mu Yang, Fang Wang, Ying Han, Ying Jiang, Yu-Xin Lei, Miao Jiang, Wen Zhang and Dong-Qi Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Research and Development Program of Shandong Province |
2021CXGC011101 |
| Special Fund for Taishan Scholars Project |
tsqn202211324 |
| National Natural Science Foundation of China |
81900669 |
| Natural Science Foundation of Shandong Province, China |
ZR2018PH007 |
| the Multidisciplinary Innovation Center for Nephrology of the Second Hospital of Shandong University |
|
|
| Corresponding Author |
Dong-Qi Tang, PhD, Academic Research, Center for Gene and Immunotherapy, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Road, Jinan 250033, Shandong Province, China. tangdq@sdu.edu.cn |
| Key Words |
Diabetic nephropathy; Glomerular endothelial cell; β-Arrestin-2; Activating transcription factor 6; Endoplasmic reticulum stress |
| Core Tip |
This study investigates the role of β-arrestin-2 in glomerular endothelial cells (GENC) in the context of diabetic nephropathy (DN). Under DN conditions, upregulated β-arrestin-2 increases the expression of activating transcription factor 6 (ATF6) and facilitates its translocation into the nucleus. This activation of endoplasmic reticulum stress induces apoptosis in GENC, exacerbating renal damage. Silencing β-arrestin-2 alleviated renal injury and GENC apoptosis both in vivo and in vitro, suggesting that β-arrestin-2 could be a promising therapeutic target for the clinical management of patients with DN. |
| Publish Date |
2024-11-18 03:30 |
| Citation |
<p>Liu J, Song XY, Li XT, Yang M, Wang F, Han Y, Jiang Y, Lei YX, Jiang M, Zhang W, Tang DQ. β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury through activating transcription factor 6 in diabetic nephropathy. <i>World J Diabetes</i> 2024; 15(12): 2322-2337</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i12/2322.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i12.2322 |
