| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Rong Shang, Jin Zhu, Lu Bai, Delida Kulabiek, Xiao-Xue Zhai, Xia Zheng and Jun Qian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Traditional Chinese Medicine Inheritance and Innovation Platform Construction Project by National Administration of Traditional Chinese Medicine |
Y2020CX57 |
| Jiangsu Provincial Administration of Traditional Chinese Medicine |
MS2023014 |
| Jiangsu Graduate Student Research and Practice Innovation Program |
SJCX23_0799 |
|
| Corresponding Author |
Jun Qian, Doctor, MD, Chief Physician, Doctor, Doctor, Professor, Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210000, Jiangsu Province, China. jun_qian@njucm.edu.cn |
| Key Words |
Gastric cancer; Adipocytes; Obesity; Tumor biomarker; Cancer associated adipocytes |
| Core Tip |
Adipocytes within tumor tissue [cancer-associated adipocytes (CAA)] play a crucial role in gastric cancer (GC) progression and patient prognosis. This study confirms that increased CAA expression correlates with adverse GC outcomes, independent of pathological features but potentially linked to patient age. A prognostic model based on key factors offers high accuracy for clinical decisions. Genes like ADH1B, SFRP1, PLAC9, and FABP4 show diagnostic and prognostic promise with high CAA expression. Immune analysis reveals reduced immune cells in high CAA GC, suggesting increased tumor aggressiveness. These findings underscore the significance of adipocytes in GC, offering potential biomarkers for future diagnostics and therapeutics. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
Shang JR, Zhu J, Bai L, Kulabiek D, Zhai XX, Zheng X, Qian J. Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features. World J Gastrointest Oncol 2024; 16(7): 3011-3031 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/3011.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.3011 |
