Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93044
Country	China

Received	2024-02-18 03:17
Peer-Review Started	2024-02-18 03:18
To Make the First Decision
Return for Revision	2024-04-13 05:40
Revised	2024-04-23 08:33
Second Decision	2024-05-07 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-07 06:17
Articles in Press	2024-05-07 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-24 02:24
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Integrated single-cell and bulk RNA sequencing revealed an epigenetic signature predicts prognosis and tumor microenvironment colorectal cancer heterogeneity
Manuscript Source	Unsolicited Manuscript
All Author List	Han-Xuan Liu, Jie Feng, Jing-Jing Jiang, Wan-Jun Shen, Yu Zheng, Gang Liu and Xiang-Yang Gao
ORCID	Author(s) ORCID Number Gang Liu http://orcid.org/0000-0003-1809-1214
Funding Agency and Grant Number
Corresponding Author	Gang Liu, PhD, Academic Fellow, Assistant Professor, Institutes of Biomedical Sciences, Fudan University, No. 131 Dongan Rd, Shanghai 200032, China. liugang@fudan.edu.cn
Key Words	Epigenetic regulation; Colorectal cancer; Micro-environment; Prognosis; Gene expression signature
Core Tip	Epigenetic regulation has been widely reported to play a role in colorectal cancer (CRC). In this work, a prognostic signature of epigenetically regulated genes was constructed and validated. The signature reflects various biological features of CRC, especially the microenvironment. It also has outstanding performance for CRC prognosis prediction.
Publish Date	2024-07-12 15:55
Citation	<p>Liu HX, Feng J, Jiang JJ, Shen WJ, Zheng Y, Liu G, Gao XY. Integrated single-cell and bulk RNA sequencing revealed an epigenetic signature predicts prognosis and tumor microenvironment colorectal cancer heterogeneity. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3032-3054</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/3032.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.3032

Full Article (PDF)	WJGO-16-3032-with-cover.pdf
Manuscript File	93044_Auto_Edited-YJP.docx
Answering Reviewers	93044-answering-reviewers.pdf
Audio Core Tip	93044-audio.mp3
Biostatistics Review Certificate	93044-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93044-conflict-of-interest-statement.pdf
Copyright License Agreement	93044-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	93044-non-native-speakers.pdf
Peer-review Report	93044-peer-reviews.pdf
Scientific Misconduct Check	93044-scientific-misconduct-check.jpg
Scientific Editor Work List	93044-scientific-editor-work-list.pdf
CrossCheck Report	93044-crosscheck-report.pdf