Publication Name	World Journal of Diabetes
Manuscript ID	93130
Country	China

Received	2024-02-20 11:57
Peer-Review Started	2024-02-20 11:57
To Make the First Decision
Return for Revision	2024-09-01 22:26
Revised	2024-09-15 02:28
Second Decision	2024-10-23 01:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-31 09:54
Articles in Press	2024-10-31 09:54
Publication Fee Transferred	2024-11-03 10:05
Edit the Manuscript by Language Editor	2024-11-21 08:26
Typeset the Manuscript	2024-11-27 09:09
Publish the Manuscript Online	2024-12-30 09:47

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress
Manuscript Source	Unsolicited Manuscript
All Author List	Chong-Xi Yuan, Xuan Wang, Yun Liu, Tian-Cheng Xu, Zhi Yu and Bin Xu
ORCID	Author(s) ORCID Number Chong-Xi Yuan http://orcid.org/0000-0001-5052-1072 Xuan Wang http://orcid.org/0000-0002-0516-6101 Yun Liu http://orcid.org/0000-0002-0451-184X Tian-Cheng Xu http://orcid.org/0000-0003-0089-0712 Zhi Yu http://orcid.org/0000-0002-9179-2618 Bin Xu http://orcid.org/0000-0003-4006-3009
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82074532 National Natural Science Foundation of China 82374577 National Natural Science Foundation of China 82305376 National Natural Science Foundation of China 82405567 The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Corresponding Author	Bin Xu, PhD, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn
Key Words	Electroacupuncture; Type 2 diabetic peripheral neuropathy; Silent matching type information regulation 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1α axis; Mitochondria biogenesis; Oxidative stress
Core Tip	Diabetic peripheral neuropathy (DPN) is believed to be related to the vicious cycle of oxidative stress and mitochondrial dysfunction caused by metabolic abnormalities. Electroacupuncture (EA) is widely used in the clinical adjuvant treatment of DPN. However, the specific mechanism is unclear up to now. In our experiment, the rat model of DPN was established by feeding high-fat diet combined with injection of streptozotocin. The final results indicate that the improvement effect of EA on DPN rats may be related to the regulation of SIRT1/PGC-1α axis which not only activate mitochondrial biogenesis, but also reduce oxidative stress and protect undamaged mitochondria.
Publish Date	2024-12-30 09:47
Citation	<p>Yuan CX, Wang X, Liu Y, Xu TC, Yu Z, Xu B. Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress. <i>World J Diabetes</i> 2025; 16(2): 93130</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i2/93130.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i2.93130

Full Article (PDF)	WJD-16-93130-with-cover.pdf
The ARRIVE Guidelines	93130-The-ARRIVE-Guidelines.pdf
Manuscript File	93130_Auto_Edited_062312.docx
Answering Reviewers	93130-answering-reviewers.pdf
Audio Core Tip	93130-audio.m4a
Biostatistics Review Certificate	93130-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93130-conflict-of-interest-statement.pdf
Copyright License Agreement	93130-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93130-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	93130-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	93130-non-native-speakers.pdf
Peer-review Report	93130-peer-reviews.pdf
Journal Editor-in-Chief Review Report	93130-journal-editor-in-chief.pdf
Scientific Misconduct Check	93130-scientific-misconduct-check.png
Scientific Editor Work List	93130-scientific-editor-work-list.pdf
CrossCheck Report	93130-crosscheck-report.png
CrossCheck Report	93130-crosscheck-report.pdf