Publication Name	World Journal of Gastroenterology
Manuscript ID	9316
Country	China

Received	2014-01-30 10:41
Peer-Review Started	2014-02-08 09:40
To Make the First Decision	2014-02-28 14:53
Return for Revision	2014-03-13 09:28
Revised	2014-04-22 22:43
Second Decision	2014-05-14 09:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-14 09:29
Articles in Press	2014-05-23 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-21 16:19
Typeset the Manuscript	2014-10-30 15:14
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Xiang Chu, Wei-Hong Wang, Yun Dai, Gui-Gen Teng and Shu-Jun Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81172271 Specialized Research Fund for the Doctoral Program of Higher Education 20110001110064
Corresponding Author	Wei-Hong Wang, Professor, Department of Gastroenterology, Peking University First Hospital, 8 Xishiku Avenue, Xicheng District, Beijing 100034, China. wangweihong@medmail.com.cn
Key Words	Helicobacter pylori; Esophagus; Metaplasia; Adenocarcinoma; Animal model
Core Tip	The relationship between gastroesophageal reflux disease and Helicobacter pylori (H. pylori) is controversial. This study demonstrates that esophageal H. pylori colonization can aggravate esophageal injury and promote the incidence of Barrett’s esophagus and esophageal adenocarcinoma. Gastric H. pylori colonization did not aggravate esophageal mucosal lesions in rats with mixed reflux. However, esophageal H. pylori infection was associated with increased cell proliferation and apoptosis in the esophagi of rats with mixed reflux. Loss of balance between cell proliferation and apoptosis may be important in H. pylori-induced esophageal malignancy.
Publish Date	2014-11-17 15:12
Citation	Chu YX, Wang WH, Dai Y, Teng GG, Wang SJ. Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux. World J Gastroenterol 2014; 20(42): 15715-15726
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15715.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15715

Full Article (PDF)	WJG-20-15715.pdf
Full Article (Word)	WJG-20-15715.doc
Manuscript File	9316-Review.doc
Answering Reviewers	9316-Answering reviewers.pdf
Copyright License Agreement	9316-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9316-Language certificate.pdf
Peer-review Report	9316-Peer reviews.pdf
Scientific Editor Work List	9316-Scientific editor work list.pdf