| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prediction of pathological complete response and prognosis in locally advanced rectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Jun Xu, Dan Tao, Song-Bing Qin, Xiao-Yan Xu, Kai-Wen Yang, Zhong-Xu Xing, Ju-Ying Zhou, Yang Jiao and Li-Li Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82073476 |
| National Key R&D Program of China |
2022YFC2503700, 2022YFC2503703 |
| Jiangsu Provincial Medical Key Discipline |
ZDXK202235 |
| Innovation Research Project of Medical and Industrial Cooperation in Suzhou |
SLJ2021005 |
|
| Corresponding Author |
Li-Li Wang, MD, Chief Physician, Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. wanglili@suda.edu.cn |
| Key Words |
Locally advanced rectal cancer; Neoadjuvant chemoradiotherapy; Pathological complete response; Carcinoembryonic antigen; Inflammation-related markers; Tumor deposit; Prognosis |
| Core Tip |
At present, there are no clinical indicators clearly related to the efficacy and long-term outcomes of neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC). In this study, inflammation-related markers and tumor deposits (TDs) were added. The final results showed that pretreatment carcinoembryonic antigen ≤ 5 ng/mL, lymphocyte-monocyte ratio > 2.73, and time interval between neoadjuvant therapy completion and total mesorectal excision > 10 wk are independent predictors of nCRT efficacy in LARC patients. Patients achieving pCR have longer disease-free survival and overall survival. Among patients without pCR, TDs are positively correlated with poor prognosis. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
<p>Xu YJ, Tao D, Qin SB, Xu XY, Yang KW, Xing ZX, Zhou JY, Jiao Y, Wang LL. Prediction of pathological complete response and prognosis in locally advanced rectal cancer. <i>World J Gastrointest Oncol</i> 2024; 16(6): 2520-2530</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2520.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2520 |
