Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93218
Country	China

Received	2024-02-22 03:03
Peer-Review Started	2024-02-22 03:03
To Make the First Decision
Return for Revision	2024-03-08 06:28
Revised	2024-04-02 06:39
Second Decision	2024-04-24 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-24 05:27
Articles in Press	2024-04-24 05:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-14 12:35
Publish the Manuscript Online	2024-06-15 02:49

ISSN	1948-5204 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Min Yao, Rong-Fei Fang, Qun Xie, Min Xu, Wen-Li Sai and Deng-Fu Yao
ORCID	Author(s) ORCID Number Min Yao http://orcid.org/0000-0002-5473-0186 Rong-Fei Fang http://orcid.org/0000-0002-3255-5014 Qun Xie http://orcid.org/0000-0002-4798-513X Min Xu http://orcid.org/0009-0006-5139-9914 Wen-Li Sai http://orcid.org/0000-0002-9618-2720 Deng-Fu Yao http://orcid.org/0000-0002-3448-7756
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81673241 and No. 31872738 Nantong Infectious Disease Alliance Fund No. 202308001
Corresponding Author	Deng-Fu Yao, MD, PhD, Professor, Department of Immunology, Medical School of Nantong University and Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Hepatocarcinogenesis; Cell signals; Specific biomarkers; Early diagnosis
Core Tip	The early monitoring or diagnosis of hepatocellular carcinoma (HCC) are still medical challenge, and identifying novel biomarkers with high sensitivity and specificity for HCC are urgently needed. Recent progress in several oncogenic cellular signalling molecules that derived from different signalling pathways were reviewed, such as novel high mobility group-Box 3, angiopoietin-2, Golgi protein 73, glypican-3, Wnt3a (a signalling molecule in the Wnt/β-catenin pathway), and secretory clusterin. They might not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for HCC therapy.
Publish Date	2024-06-15 02:49
Citation	<p>Yao M, Fang RF, Xie Q, Xu M, Sai WL, Yao DF. Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(6): 2350-2361</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i6/2350.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i6.2350

Full Article (PDF)	WJGO-16-2350-with-cover.pdf
Manuscript File	93218_Auto_Edited-YJP.docx
Answering Reviewers	93218-answering-reviewers.pdf
Audio Core Tip	93218-audio.mp3
Conflict-of-Interest Disclosure Form	93218-conflict-of-interest-statement.pdf
Copyright License Agreement	93218-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93218-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	93218-non-native-speakers.pdf
Peer-review Report	93218-peer-reviews.pdf
Scientific Misconduct Check	93218-scientific-misconduct-check.jpg
Scientific Editor Work List	93218-scientific-editor-work-list.pdf
CrossCheck Report	93218-crosscheck-report.pdf