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Articles Published Processes
6/29/2024 10:30:35 AM | Browse: 85 | Download: 222
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Received |
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2024-02-22 07:00 |
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Peer-Review Started |
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2024-02-22 07:00 |
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To Make the First Decision |
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Return for Revision |
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2024-04-17 08:08 |
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2024-04-24 13:17 |
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Second Decision |
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2024-05-11 09:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-05-11 09:58 |
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Articles in Press |
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2024-05-11 09:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-06-13 08:35 |
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Publish the Manuscript Online |
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2024-06-29 10:30 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Report |
| Article Title |
Analysis of an adult diabetes mellitus caused by a rare mutation of the gene: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Xuan Li, Li-Li Xu, Chuan-Feng Liu, Bing-Zi Dong and Yun-Yang Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Li-Li Xu, PhD, Doctor, Doctor, Department of Endocrine and Metabolic Diseases, The Affiliated Hospital Of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao 266003, Shandong Province, China. qdfyxll@qdu.edu.cn |
| Key Words |
Diabetes; Gene mutation; Maturity-onset diabetes of the young; Peroxisome proliferator-activated receptor gamma; Lipid metabolism |
| Core Tip |
The results from the gene detection process demonstrated a heterozygous mutation of guanine (G) at position 284 in the coding region of exon 2 of peroxisome proliferator-activated receptor gamma (PPARG), which replaced the base adenine (A) (exon 2 c. 284A>G p.Tyr95Cys). This missense mutation resulted in the substitution of tyrosine with cysteine at the 95th position of the translated protein. Notably, both of the patient’s siblings harbored a nucleotide heterozygous variation at the same site, and both were diagnosed with diabetes, suggesting that the PPARG gene mutation, particularly the p.Tyr95Cys mutation, may represent a newly identified subtype of maturity-onset diabetes of the young. This subtype is characterized by insulin resistance and lipid metabolism disorders. |
| Publish Date |
2024-06-29 10:30 |
| Citation |
<p>Li WX, Xu LL, Liu CF, Dong BZ, Wang YY. Analysis of an adult diabetes mellitus caused by a rare mutation of the gene: A case report. <i>World J Clin Cases</i> 2024; 12(19): 3942-3949</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i19/3942.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i19.3942 |
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