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Articles Published Processes
7/8/2024 7:49:58 AM | Browse: 138 | Download: 942
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Received |
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2024-02-22 13:33 |
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Peer-Review Started |
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2024-02-22 13:33 |
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First Decision by Editorial Office Director |
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2024-04-17 22:07 |
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Return for Revision |
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2024-04-18 01:39 |
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Revised |
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2024-04-28 08:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-05-07 11:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-05-20 08:07 |
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Articles in Press |
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2024-05-20 08:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-06-20 07:40 |
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Publish the Manuscript Online |
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2024-07-08 07:49 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Luo, Yue Zhou, Li-Ying Wang and Lei Ai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32200944 |
| “Qing Lan” Project of Jiangsu Province |
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| Jiangsu Research Institute of Sports Science Foundation |
BM-2022-03 |
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| Corresponding Author |
Lei Ai, PhD, Associate Research Scientist, Department of Sports Physiology Research, Jiangsu Research Institute of Sports Science, No. 169 Xianlin Avenue, Nanjing 210033, Jiangsu Province, China. ailei_982@163.com |
| Key Words |
Macrophages phenotype; Myoblasts; Cross-talk; Glucose toxicity; Chronic inflammation; Insulin sensitivity |
| Core Tip |
This study demonstrated interactions between myoblasts and macrophages under high glucose (HG) milieus induced pro-inflammatory M1 polarization of macrophages to exacerbate inflammatory response. Subsequently, chronic inflammation induced by HG-related M1 macrophages damaged myogenesis and insulin sensitivity in myoblasts. Ultimately, interactions between myoblasts and macrophages resulted in skeletal muscle insulin resistance (IR), which supported macrophage may serve as a promising therapeutic target for skeletal muscle atrophy and IR. This is the first research about the mediation of macrophages to HG-related myogenic inhibition and IR in myoblasts, which provide new insights into the prevention and treatment of skeletal muscle atrophy and IR. |
| Publish Date |
2024-07-08 07:49 |
| Citation |
Luo W, Zhou Y, Wang LY, Ai L. Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity. World J Diabetes 2024; 15(7): 1589-1602 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i7/1589.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i7.1589 |
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