Publication Name	World Journal of Diabetes
Manuscript ID	93244
Country	China

Received	2024-02-22 13:33
Peer-Review Started	2024-02-22 13:33
To Make the First Decision
Return for Revision	2024-04-18 01:39
Revised	2024-04-28 08:39
Second Decision	2024-05-07 11:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-20 08:07
Articles in Press	2024-05-20 08:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-20 07:40
Publish the Manuscript Online	2024-07-08 07:49

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Luo, Yue Zhou, Li-Ying Wang and Lei Ai
ORCID	Author(s) ORCID Number Lei Ai http://orcid.org/0000-0002-8406-3900
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32200944 “Qing Lan” Project of Jiangsu Province Jiangsu Research Institute of Sports Science Foundation BM-2022-03
Corresponding Author	Lei Ai, PhD, Associate Research Scientist, Department of Sports Physiology Research, Jiangsu Research Institute of Sports Science, No. 169 Xianlin Avenue, Nanjing 210033, Jiangsu Province, China. ailei_982@163.com
Key Words	Macrophages phenotype; Myoblasts; Cross-talk; Glucose toxicity; Chronic inflammation; Insulin sensitivity
Core Tip	This study demonstrated interactions between myoblasts and macrophages under high glucose (HG) milieus induced pro-inflammatory M1 polarization of macrophages to exacerbate inflammatory response. Subsequently, chronic inflammation induced by HG-related M1 macrophages damaged myogenesis and insulin sensitivity in myoblasts. Ultimately, interactions between myoblasts and macrophages resulted in skeletal muscle insulin resistance (IR), which supported macrophage may serve as a promising therapeutic target for skeletal muscle atrophy and IR. This is the first research about the mediation of macrophages to HG-related myogenic inhibition and IR in myoblasts, which provide new insights into the prevention and treatment of skeletal muscle atrophy and IR.
Publish Date	2024-07-08 07:49
Citation	<p>Luo W, Zhou Y, Wang LY, Ai L. Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity. <i>World J Diabetes</i> 2024; 15(7): 1589-1602</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i7/1589.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i7.1589

Full Article (PDF)	WJD-15-1589-with-cover.pdf
The ARRIVE Guidelines	93244-The-ARRIVE-Guidelines.pdf
Manuscript File	93244_Auto_Edited-YJP.docx
Answering Reviewers	93244-answering-reviewers.pdf
Audio Core Tip	93244-audio.mp3
Biostatistics Review Certificate	93244-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93244-conflict-of-interest-statement.pdf
Copyright License Agreement	93244-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93244-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	93244-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	93244-non-native-speakers.pdf
Peer-review Report	93244-peer-reviews.pdf
Journal Editor-in-Chief Review Report	93244-journal-editor-in-chief.pdf
Scientific Misconduct Check	93244-scientific-misconduct-check.png
Scientific Editor Work List	93244-scientific-editor-work-list.pdf
Scientific Editor Work List	93244-scientific-editor-work-list.pdf
CrossCheck Report	93244-crosscheck-report.png
CrossCheck Report	93244-crosscheck-report.pdf