Publication Name	World Journal of Cardiology
Manuscript ID	93255
Country	Saudi Arabia

Received	2024-02-22 20:17
Peer-Review Started	2024-02-22 20:17
To Make the First Decision
Return for Revision	2024-04-18 19:15
Revised	2024-05-21 08:18
Second Decision	2024-05-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-24 08:16
Articles in Press	2024-05-24 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-30 06:34
Publish the Manuscript Online	2024-06-25 10:25

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Establishing delivery route-dependent safety and efficacy of living biodrug mesenchymal stem cells in heart failure patients
Manuscript Source	Invited Manuscript
All Author List	Muhammad Candragupta Jihwaprani, Idris Sula, Mohamed Ahmed Charbat and Khawaja Husnain Haider
ORCID	Author(s) ORCID Number Khawaja Husnain Haider http://orcid.org/0000-0002-7907-4808
Funding Agency and Grant Number
Corresponding Author	Khawaja Husnain Haider, BPharm, BSc, PhD, Chairman, Full Professor, Basic Sciences, SRC, AlMadina Road, Al Bukayriyah 52736, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Key Words	Clinical trial; Heart failure; Mesenchymal stem cells; Living biodrug; Meta-analysis; Stem cells; Systematic review
Core Tip	Route of delivery (RoD) remains a critical determinant of safety and efficacy in cardiac stem cell therapy, particularly in heart failure (HF) patients. HF occurs when the heart’s pumping ability is inadequate to meet the body’s metabolic needs. Mesenchymal stem cells (MSCs) are living biopharmaceuticals with unique properties that need to be administered such that they reach the target site and are retained there to participate in the repair process. This systematic review and meta-analysis of phase II randomized clinical trials determine the RoD effect on the safety and efficacy of MSCs during HF treatment.
Publish Date	2024-06-25 10:25
Citation	<p>Jihwaprani MC, Sula I, Charbat MA, Haider KH. Establishing delivery route-dependent safety and efficacy of living biodrug mesenchymal stem cells in heart failure patients. <i>World J Cardiol</i> 2024; 16(6): 339-354</p>
URL	https://www.wjgnet.com/1949-8462/full/v16/i6/339.htm
DOI	https://dx.doi.org/10.4330/wjc.v16.i6.339

Full Article (PDF)	WJC-16-339-with-cover.pdf
PRISMA 2009 Checklist	93255-PRISMA-2009-Checklist.pdf
Manuscript File	93255_Auto_Edited-YJP.docx
Answering Reviewers	93255-answering-reviewers.pdf
Audio Core Tip	93255-audio.mp3
Biostatistics Review Certificate	93255-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93255-conflict-of-interest-statement.pdf
Copyright License Agreement	93255-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	93255-non-native-speakers.pdf
Supplementary Material	93255-supplementary-material.pdf
Peer-review Report	93255-peer-reviews.pdf
Scientific Misconduct Check	93255-scientific-misconduct-check.png
Scientific Editor Work List	93255-scientific-editor-work-list.pdf
CrossCheck Report	93255-crosscheck-report.pdf