Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93272
Country	China

Received	2024-02-23 09:59
Peer-Review Started	2024-02-23 09:59
To Make the First Decision
Return for Revision	2024-04-13 05:30
Revised	2024-04-29 07:38
Second Decision	2024-05-17 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-17 06:24
Articles in Press	2024-05-17 06:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-24 00:12
Publish the Manuscript Online	2024-07-12 15:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage
Manuscript Source	Unsolicited Manuscript
All Author List	Miao Yu, Qian Chen and Yi-Ping Lu
ORCID	Author(s) ORCID Number Yi-Ping Lu http://orcid.org/0009-0007-7556-4088
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Hospital Research and Cultivation Program Project PZ2022008
Corresponding Author	Yi-Ping Lu, MM, Chief Physician, Department of Surgical Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23 Art Museum Back Street, Beijing 100010, China. 15210712026@163.com
Key Words	Aldehyde dehydrogenase 2 family member; Colorectal cancer; Acetaldehyde; Apoptosis; DNA damage; JNK/p38 MAPK
Core Tip	This work demonstrated that aldehyde dehydrogenase 2 family member (ALDH2) repression caused the accumulation of acetaldehyde, inducing cell apoptosis and DNA damage by means of activating the JNK/p38 MAPK signaling pathway in colorectal cancer (CRC). ALDH2 is utilized as a therapeutic target for reversing patients with CRC.
Publish Date	2024-07-12 15:55
Citation	<p>Yu M, Chen Q, Lu YP. Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage. <i>World J Gastrointest Oncol</i> 2024; 16(7): 3230-3240</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i7/3230.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i7.3230

Full Article (PDF)	WJGO-16-3230-with-cover.pdf
The ARRIVE Guidelines	93272-The-ARRIVE-Guidelines.pdf
Manuscript File	93272_Auto_Edited-YJP.docx
Answering Reviewers	93272-answering-reviewers.pdf
Audio Core Tip	93272-audio.m4a
Biostatistics Review Certificate	93272-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93272-conflict-of-interest-statement.pdf
Copyright License Agreement	93272-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93272-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	93272-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	93272-non-native-speakers.pdf
Peer-review Report	93272-peer-reviews.pdf
Scientific Misconduct Check	93272-scientific-misconduct-check.png
Scientific Editor Work List	93272-scientific-editor-work-list.pdf
CrossCheck Report	93272-crosscheck-report.pdf