Publication Name	World Journal of Hepatology
Manuscript ID	93287
Country	Ethiopia

Received	2024-02-23 18:35
Peer-Review Started	2024-02-23 18:35
To Make the First Decision
Return for Revision	2024-04-29 19:57
Revised	2024-06-14 04:42
Second Decision	2024-07-05 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-05 07:49
Articles in Press	2024-07-05 07:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-07-10 17:18
Typeset the Manuscript	2024-07-15 07:14
Publish the Manuscript Online	2024-07-26 10:33

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Chronic hepatitis B virus infection in Eastern Ethiopia: Clinical characteristics and determinants of cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Nejib Y Ismael, Semir A Usmael, Nega B Belay, Hailemichael Desalegn Mekonen, Asgeir Johannessen and Stian MS Orlien
ORCID	Author(s) ORCID Number Nejib Y Ismael http://orcid.org/0000-0002-4588-7333 Semir A Usmael http://orcid.org/0000-0003-4221-5694 Nega B Belay http://orcid.org/0000-0001-6959-9897 Hailemichael Desalegn Mekonen http://orcid.org/0000-0003-2042-5797 Asgeir Johannessen http://orcid.org/0000-0001-5966-7166 Stian MS Orlien http://orcid.org/0000-0002-1422-5708
Funding Agency and Grant Number	Funding Agency Grant Number Norwegian Research Council 220622/H10
Corresponding Author	Semir A Usmael, MD, Assistant Professor, Department of Internal Medicine, Haramaya University, College of Health and Medical Sciences, Jinella Street, Harar 252, Ethiopia. semirabdi61@gmail.com
Key Words	Chronic hepatitis B; Cirrhosis; Cohort study; Resource-limited settings; Sub-Saharan Africa
Core Tip	In this study, we investigated the characteristics and efficacy of antiviral treatment in 193 patients who were human immunodeficiency virus-negative and participated in a pilot chronic hepatitis B treatment program in Eastern Ethiopia. Notably, one-third of the patients had cirrhosis at enrollment, reflecting poor access to hepatitis B virus services in the study area. Tenofovir disoproxil fumarate treatment was highly effective in achieving viral suppression and improving the levels of liver fibrosis markers. However, the initial mortality rate was high owing to the high proportion of patients with decompensated cirrhosis. This finding highlights the importance of scaling up national hepatitis B virus prevention and control programs.
Publish Date	2024-07-26 10:33
Citation	<p>Ismael NY, Usmael SA, Belay NB, Mekonen HD, Johannessen A, Orlien SM. Chronic hepatitis B virus infection in Eastern Ethiopia: Clinical characteristics and determinants of cirrhosis. <i>World J Hepatol</i> 2024; 16(7): 995-1008</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i7/995.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i7.995

Full Article (PDF)	WJH-16-995-with-cover.pdf
STROBE Statement	93287-STROBE-statement.pdf
Manuscript File	93287_Auto_Edited_084742.docx
Answering Reviewers	93287-answering-reviewers.pdf
Audio Core Tip	93287-audio.wav
Biostatistics Review Certificate	93287-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93287-conflict-of-interest-statement.pdf
Copyright License Agreement	93287-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93287-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	93287-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	93287-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	93287-non-native-speakers.pdf
Peer-review Report	93287-peer-reviews.pdf
Scientific Misconduct Check	93287-scientific-misconduct-check.png
Scientific Editor Work List	93287-scientific-editor-work-list.pdf
CrossCheck Report	93287-crosscheck-report.pdf