6/25/2024 10:41:21 AM | Browse: 61 | Download: 292
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 93313 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Microbiology | ||||||||||
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| Manuscript Type | Basic Study | ||||||||||
| Article Title | Effect and mechanism of the Qingre Huashi Decoction on drug-resistance Helicobacter pylori through nonspecific pathways | ||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||
| All Author List | Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye and Xue-Zhi Zhang | ||||||||||
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| Corresponding Author | Xue-Zhi Zhang, MD, PhD, Chief Physician, Professor, Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. zhang.xuezhi@263.net | ||||||||||
| Key Words | Qingre Huashi Decoction; Helicobacter pylori; Drug resistance; Biofilm; Metabolomics | ||||||||||
| Core Tip | Helicobacter pylori (HP) infection affects over 4.4 billion people worldwide, with its multidrug resistance posing a serious challenge. Twelve strains of HP were isolated in vitro following biopsy during gastroscopy of HP-infected patients, with the most robust biofilm-forming strain of HP being selected to investigate the effect and mechanism of Qingre Huashi Decoction (QHD) on drug-resistance HP through nonspecific pathways. QHD has bacteriostatic and bactericidal effects on HP, reduces HP drug-resistance by inhibiting biofilm formation, destroying biofilm structure, inhibiting biofilm-related and efflux pump-related gene expression, enhancing HP metabolism, and activating AMP in HP. | ||||||||||
| Publish Date | 2024-06-25 10:41 | ||||||||||
| Citation | <p>Lin MM, Yang SS, Huang QY, Cui GH, Jia XF, Yang Y, Shi ZM, Ye H, Zhang XZ. Effect and mechanism of the Qingre Huashi Decoction on drug-resistance Helicobacter pylori through nonspecific pathways. <i>World J Gastroenterol</i> 2024; 30(24): 3086-3105</p> | ||||||||||
| URL | https://www.wjgnet.com/1007-9327/full/v30/i24/3086.htm | ||||||||||
| DOI | https://dx.doi.org/10.3748/wjg.v30.i24.3086 |
| Full Article (PDF) | WJG-30-3086-with-cover.pdf |
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| Manuscript File | 93313_Auto_Edited-YJP_WangTQ.docx |
| Answering Reviewers | 93313-answering-reviewers.pdf |
| Audio Core Tip | 93313-audio.MP3 |
| Biostatistics Review Certificate | 93313-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 93313-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 93313-copyright-assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 93313-foundation-statement.pdf |
| Institutional Review Board Approval Form or Document | 93313-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 93313-non-native-speakers.pdf |
| Supplementary Material | 93313-supplementary-material.pdf |
| Peer-review Report | 93313-peer-reviews.pdf |
| Scientific Misconduct Check | 93313-scientific-misconduct-check.png |
| Scientific Editor Work List | 93313-scientific-editor-work-list.pdf |
| CrossCheck Report | 93313-crosscheck-report.pdf |