| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Hong, Bo Wang, Hang-Cheng Zhou, Zheng-Xiang Wu, Hua-Ying Fang, Geng-Qing Song and Yue Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
31870993 |
|
| Corresponding Author |
Yue Yu, MD, PhD, Chief Doctor, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. yuyuemd@163.com |
| Key Words |
Ulcerative colitis; Hepatocarcinoma; Immune checkpoint inhibitor-associated colitis; Colectomy; Case report |
| Core Tip |
Immune checkpoint inhibitors, such as immune checkpoint inhibitor-associated colitis, have demonstrated significant efficacy in treating various advanced malignant tumors, but several immune-related adverse drug reactions, such as immune checkpoint inhibitor-associated colitis, have attracted increasing attention. In this article, we present a case of a patient with hepatocarcinoma and ulcerative colitis with ICI-related colitis in which repeated life-threatening lower gastrointestinal hemorrhage occurred during the disease course. Despite comprehensive salvage treatments through multidisciplinary management, the patient eventually required surgical intervention due to persistent gastrointestinal bleeding. This case highlights the necessity of early identification, timely and adequate treatment of ICI-related colitis and rapid escalation to improve patient prognosis. |
| Publish Date |
2024-07-22 11:57 |
| Citation |
<p>Hong N, Wang B, Zhou HC, Wu ZX, Fang HY, Song GQ, Yu Y. Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage: A case report. <i>World J Gastrointest Surg</i> 2024; 16(7): 2329-2336</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v16/i7/2329.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i7.2329 |
