| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Agriculture, Dairy & Animal Science |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Unraveling the mechanism of malancao in treating ulcerative colitis: A multi-omics approach
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Long Huang, Lu-Na Wu, Qin Huang, Yue Zhou, Lei Qing, Feng Xiong, Hui-Ping Dong, Tai-Min Zhou, Kai-Li Wang and Jue Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Chongqing Science and Health Joint Chinese Medicine Technology Innovation and Application Development Project |
No. 2022MSXM209 |
|
| Corresponding Author |
Jue Liu, PhD, Lecturer, ., Hospital of Traditional Chinese Medicine in Qijiang District, No. 69 Huideng Road, Tonghui Street, Qijiang District, Chongqing 401420, China. 30112067@qq.com |
| Key Words |
Malancao; Ulcerative colitis; Mass spectrum; Network pharmacology; Molecular docking |
| Core Tip |
Eleven primary active constituents (nicotinic acid, luteolin, kaempferol, genkwanin, bessisterol, aloe emodin, wogonin, stigmasterol, rhein, quercetin, oroxylin A) and five key genes (AKT1, JUN, HSP90AA1, CASP3, IL6) were identified in malancao (MLC). Furthermore, three principal signaling pathways were determined through enrichment analysis from the Kyoto Encyclopedia of Genes and Genomes, suggesting that MLC exhibits a multi-component, multi-target, and multi-pathway approach in the treatment of ulcerative colitis. |
| Publish Date |
2024-06-04 15:55 |
| Citation |
<p>Huang XL, Wu LN, Huang Q, Zhou Y, Qing L, Xiong F, Dong HP, Zhou TM, Wang KL, Liu J. Unraveling the mechanism of malancao in treating ulcerative colitis: A multi-omics approach. <i>World J Clin Cases</i> 2024; 12(17): 3105-3122</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i17/3105.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i17.3105 |
