Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	93508
Country	China

Received	2024-02-28 15:48
Peer-Review Started	2024-02-28 15:48
To Make the First Decision
Return for Revision	2024-04-24 04:44
Revised	2024-05-06 16:04
Second Decision	2024-06-13 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-13 06:14
Articles in Press	2024-06-13 06:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-08 03:41
Publish the Manuscript Online	2024-09-18 11:53

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Gastric cancer liver metastasis will reduce the efficacy of immunotherapy
Manuscript Source	Invited Manuscript
All Author List	Liang Wang, Shan-Shan Liu, Sheng-Mei Zhang, Xiao-Qian Chen, Tao Huang, Rong Tian, Ya-Qi Zhao, Zhou Chen and Cai-Rang Xianba
ORCID	Author(s) ORCID Number Liang Wang http://orcid.org/0000-0002-4206-5043
Funding Agency and Grant Number	Funding Agency Grant Number 2021 Key topic of Qinghai Provincial Health system – Guiding plan topic 2021-WJZDX-43
Corresponding Author	Liang Wang, PhD, Lecturer, Department of Gastrointestinal Oncology Surgery, Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, No. 29 Tongren Road, Xining 810000, Qinghai Province, China. wangliang19911128@163.com
Key Words	Immune checkpoint inhibitors; Gastric cancer; Gastric cancer with liver metastasis; Immunotherapy; Liver immune tolerance
Core Tip	Immunotherapy has found extensive application in the clinical management of advanced gastric cancer (GC), yielding notable clinical outcomes. In the context of advanced GC with liver metastasis, immunotherapy fails to elicit the desired response owing to the presence of hepatic immune tolerance mechanisms and the compromised physical condition of patients, leading to a reduction in immune response rates. Therefore, liver metastases may be associated with a lower likelihood of immunotherapy success in GC patients. Enhancing the response to immunotherapy in GC patients with liver metastases involves overcoming liver immune tolerance mechanisms and their adverse effects.
Publish Date	2024-09-18 11:53
Citation	<p>Wang L, Liu SS, Zhang SM, Chen XQ, Huang T, Tian R, Zhao YQ, Chen Z, Xianba CR. Gastric cancer liver metastasis will reduce the efficacy of immunotherapy. <i>World J Gastrointest Surg</i> 2024; 16(9): 2760-2764</p>
URL	https://www.wjgnet.com/1948-9366/full/v16/i9/2760.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i9.2760

Full Article (PDF)	WJGS-16-2760-with-cover.pdf
Manuscript File	93508_Auto_Edited-YJP.docx
Answering Reviewers	93508-answering-reviewers.pdf
Audio Core Tip	93508-audio.mp3
Conflict-of-Interest Disclosure Form	93508-conflict-of-interest-statement.pdf
Copyright License Agreement	93508-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93508-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	93508-non-native-speakers.pdf
Peer-review Report	93508-peer-reviews.pdf
Scientific Misconduct Check	93508-scientific-misconduct-check.png
Scientific Editor Work List	93508-scientific-editor-work-list.pdf
CrossCheck Report	93508-crosscheck-report.png
CrossCheck Report	93508-crosscheck-report.pdf