Publication Name	World Journal of Clinical Cases
Manuscript ID	93582
Country	China

Received	2024-03-01 08:46
Peer-Review Started	2024-03-01 08:46
To Make the First Decision
Return for Revision	2024-04-09 04:46
Revised	2024-04-23 09:38
Second Decision	2024-04-30 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-30 05:31
Articles in Press	2024-04-30 05:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-03 05:58
Publish the Manuscript Online	2024-06-18 09:29

ISSN	2307-8960 (online)
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Category	Dermatology
Manuscript Type	Clinical and Translational Research
Article Title	Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Yang Zhang, Song-Xue Guo, Lei-Lei Chen, Jia-Yan Zhu, Ming-Sheng Hou, Jia-Ke Lu and Xue-Xiang Shen
ORCID	Author(s) ORCID Number Xue-Xiang Shen http://orcid.org/0000-0003-2429-1220
Funding Agency and Grant Number	Funding Agency Grant Number 2022 Shaoxing City Health Science and Technology Program (Health Science and Technology Program) No. 2022KY050
Corresponding Author	Xue-Xiang Shen, MD, Associate Chief Physician, Department Of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine, No. 641 Renmin Middle Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. zsyzsy0522@163.com
Key Words	WuFuYin; Hypertrophic scar; Network pharmacology; Molecular docking; Enrichment analysis
Core Tip	This study identified 8 hub genes [CKD2, ABCC1, MMP2, MMP9, glycogen synthase kinase 3 beta (GSK3B), PRARG, MMP3, and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG)] and five key compounds (MOL004941, MOL004935, MOL004866, MOL004993, and MOL004989) in the WuFuYin (WFY) as an effective treatment for hypertrophic scar (HTS). We found that PI3K-Akt pathway played a crucial role in the WFY. The results of molecular docking showed that GSK3B and cyclin dependent kinase 2 affected HTS through targeting MOL004941, MOL004989, and MOL004993.
Publish Date	2024-06-18 09:29
Citation	<p>Zhang SY, Guo SX, Chen LL, Zhu JY, Hou MS, Lu JK, Shen XX. Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking. <i>World J Clin Cases</i> 2024; 12(18): 3505-3514</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i18/3505.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i18.3505

Full Article (PDF)	WJCC-12-3505-with-cover.pdf
Manuscript File	93582_Auto_Edited-JLW.docx
Answering Reviewers	93582-answering-reviewers.pdf
Audio Core Tip	93582-audio.mp3
Biostatistics Review Certificate	93582-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93582-conflict-of-interest-statement.pdf
Copyright License Agreement	93582-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93582-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	93582-non-native-speakers.pdf
Supplementary Material	93582-supplementary-material.pdf
Peer-review Report	93582-peer-reviews.pdf
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Scientific Editor Work List	93582-scientific-editor-work-list.pdf
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