| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dermatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Yang Zhang, Song-Xue Guo, Lei-Lei Chen, Jia-Yan Zhu, Ming-Sheng Hou, Jia-Ke Lu and Xue-Xiang Shen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2022 Shaoxing City Health Science and Technology Program (Health Science and Technology Program) |
No. 2022KY050 |
|
| Corresponding Author |
Xue-Xiang Shen, MD, Associate Chief Physician, Department Of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine, No. 641 Renmin Middle Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. zsyzsy0522@163.com |
| Key Words |
WuFuYin; Hypertrophic scar; Network pharmacology; Molecular docking; Enrichment analysis |
| Core Tip |
This study identified 8 hub genes [CKD2, ABCC1, MMP2, MMP9, glycogen synthase kinase 3 beta (GSK3B), PRARG, MMP3, and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG)] and five key compounds (MOL004941, MOL004935, MOL004866, MOL004993, and MOL004989) in the WuFuYin (WFY) as an effective treatment for hypertrophic scar (HTS). We found that PI3K-Akt pathway played a crucial role in the WFY. The results of molecular docking showed that GSK3B and cyclin dependent kinase 2 affected HTS through targeting MOL004941, MOL004989, and MOL004993. |
| Publish Date |
2024-06-18 09:29 |
| Citation |
<p>Zhang SY, Guo SX, Chen LL, Zhu JY, Hou MS, Lu JK, Shen XX. Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking. <i>World J Clin Cases</i> 2024; 12(18): 3505-3514</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i18/3505.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i18.3505 |
