| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Bo Tang, Le-Sha Wang, Yi-hui Wu, Li-Xia Zhang, Lu-Yao Hu, Qi Wu, Meng-Lin Zhou and Zhao-Xia Liang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key R and D Program of Zhejiang Province |
2022C03058 |
| Medical and Health Technology Program of Zhejiang Province |
WKJ-ZJ-2324 |
| 4+X Clinical Research Project of Women's Hospital, School of Medicine, Zhejiang University |
ZDFY2022-4XB101 |
|
| Corresponding Author |
Zhao-Xia Liang, PhD, Chief Physician, Doctor, Doctor, Researcher, Department of Obstetrics, Women's Hospital School of Medicine, Zhejiang University, No. 1 Xueshi Road, Hangzhou 310006, Zhejiang Province, China. xiaozaizai@zju.edu.cn |
| Key Words |
Gestational diabetes mellitus; Exercise; Glucose transporter 1; Hypoxia inducible factor-1α; Placenta; Offspring |
| Core Tip |
We established a mouse model of gestational diabetes mellitus (GDM) and an exercise model during pregnancy. We discussed placental glucose transporter (GLUT) 1 expression and the hypoxic microenvironment, and the correlation between them. We also investigated organ development in the heart, liver, and kidney of the offspring. Our findings suggest that exercise during pregnancy is beneficial for organ development in the offspring of GDM. This benefit may be realized by modulating GLUT 1 expression and improving placental hypoxia. We hope that this study will emphasize the importance of exercise during pregnancy in women with GDM to improve its effects on organ development in the offspring. |
| Publish Date |
2024-10-16 10:38 |
| Citation |
<p>Tang YB, Wang LS, Wu YH, Zhang LX, Hu LY, Wu Q, Zhou ML, Liang ZX. Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus. <i>World J Diabetes</i> 2024; 15(11): 2203-2219</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i11/2203.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i11.2203 |
