Publication Name	World Journal of Clinical Cases
Manuscript ID	93660
Country	China

Received	2024-03-03 09:55
Peer-Review Started	2024-03-03 09:55
To Make the First Decision
Return for Revision	2024-04-10 04:25
Revised	2024-04-10 14:09
Second Decision	2024-04-23 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-23 08:56
Articles in Press	2024-04-23 08:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-27 15:44
Publish the Manuscript Online	2024-05-29 12:34

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Pearls of meta-analyses and systematic review in scientific evidence
Manuscript Source	Invited Manuscript
All Author List	Sunny Chi Lik Au
ORCID	Author(s) ORCID Number Sunny Chi Lik Au http://orcid.org/0000-0002-5849-3317
Funding Agency and Grant Number
Corresponding Author	Sunny Chi Lik Au, MBChB, Chief Doctor, Surgeon, Department of Ophthalmology, Tung Wah Eastern Hospital, 9/F, MO Office, Lo Ka Chow Memorial Ophthalmic Centre, 19 Eastern Hospital Road, Causeway Bay, Hong Kong , China. kilihcua@gmail.com
Key Words	Meta-analysis; Systematic review; Methodology; Research; Journal; Academic
Core Tip	Scientific evidence evolves from case reports to randomized controlled trials. Systematic reviews and meta-analyses are crucial but can be flawed due to limited information, the so called: “Garbage in, Garbage out”. In running the meta-analysis, mathematical pooling can be invalidated by study heterogeneity, poor study quality, and publication bias. Remedial measures include exploring heterogeneity, restricting meta-analysis to systematic review in case of insufficient information, and addressing different types of bias. Remember, the pearl of meta-analyses relies on quality over quantity in evidence synthesis.
Publish Date	2024-05-29 12:34
Citation	<p>Au SCL. Pearls of meta-analyses and systematic review in scientific evidence. <i>World J Clin Cases</i> 2024; 12(16): 2701-2703</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i16/2701.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i16.2701

Full Article (PDF)	WJCC-12-2701-with-cover.pdf
Manuscript File	93660_Auto_Edited-JLW.docx
Answering Reviewers	93660-Answering reviewers.pdf
Audio Core Tip	93660-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	93660-Conflict-of-interest statement.pdf
Copyright License Agreement	93660-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	93660-Language certificate.pdf
Peer-review Report	93660-Peer-review(s).pdf
Scientific Misconduct Check	93660-Bing-Liu H-2.png
Scientific Editor Work List	93660-Scientific editor work list.pdf
CrossCheck Report	93660-CrossCheck report.pdf