Publication Name	World Journal of Gastroenterology
Manuscript ID	93671
Country	Italy

Received	2024-03-03 14:15
Peer-Review Started	2024-03-03 14:15
To Make the First Decision
Return for Revision	2024-04-24 02:26
Revised	2024-05-07 03:24
Second Decision	2024-05-28 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-28 05:52
Articles in Press	2024-05-28 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-06-01 01:14
Typeset the Manuscript	2024-06-04 05:51
Publish the Manuscript Online	2024-06-25 10:41

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Medicine, General & Internal
Manuscript Type	Editorial
Article Title	Alanine aminotransferase predicts incident steatotic liver disease of metabolic etiology. Long life to the old biomarker !
Manuscript Source	Invited Manuscript
All Author List	Amedeo Lonardo
ORCID	Author(s) ORCID Number Amedeo Lonardo http://orcid.org/0000-0001-9886-0698
Funding Agency and Grant Number
Corresponding Author	Amedeo Lonardo, MD, Academic Research, Doctor, Doctor, Professor, Senior Lecturer, Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena (2023), Ospedale Baggiovara, 41121 Modena, Modena 41126, Italy. a.lonardo@libero.it
Key Words	Alanine aminotransferase; Biomarker; History of medicine; Metabolic dysfunction-associated fatty liver disease; Metabolism; Nonalcoholic fatty liver disease; Reference range; Sex differences; Steatotic liver disease
Core Tip	The recent paper published  by Chen et al. (Chen JF, et al. World Journal of Gastroenterology doi: 10.3748/wjg.v30.i10.1346) has two main findings. First, > 80% of individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) had normal alanine aminotransferase (ALT) levels. Second, there was a linear increasing trend in the association between cumulative excess high-normal ALT levels and the rate of incident MAFLD. Future studies on steatotic liver disease owing to metabolic dysfunction should adopt locally determined and prospectively validated reference ranges of ALT and carefully consider sex differences in liver enzymes and pathobiology of MAFLD. The recent paper published  by Chen et al. (Chen JF, et al. World Journal of Gastroenterology doi: 10.3748/wjg.v30.i10.1346) has two main findings. First, > 80% of individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) had normal alanine aminotransferase (ALT) levels. Second, there was a linear increasing trend in the association between cumulative excess high-normal ALT levels and the rate of incident MAFLD. Future studies on steatotic liver disease owing to metabolic dysfunction should adopt locally determined and prospectively validated reference ranges of ALT and carefully consider sex differences in liver enzymes and pathobiology of MAFLD.
Publish Date	2024-06-25 10:41
Citation	<p>Lonardo A. Alanine aminotransferase predicts incident steatotic liver disease of metabolic etiology. Long life to the old biomarker ! . <i>World J Gastroenterol</i> 2024; 30(24): 3016-3021</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i24/3016.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i24.3016

Full Article (PDF)	WJG-30-3016-with-cover.pdf
Manuscript File	93671_Revision_Auto_Edited.docx
Answering Reviewers	93671-answering-reviewers.pdf
Audio Core Tip	93671-audio.mp3
Conflict-of-Interest Disclosure Form	93671-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	93671-non-native-speakers.pdf
Peer-review Report	93671-peer-reviews.pdf
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Scientific Editor Work List	93671-scientific-editor-work-list.pdf
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