Publication Name	World Journal of Clinical Oncology
Manuscript ID	93717
Country	Portugal

Received	2024-03-04 19:28
Peer-Review Started	2024-03-04 19:29
To Make the First Decision
Return for Revision	2024-07-09 21:02
Revised	2024-07-22 18:18
Second Decision	2024-08-15 04:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-15 09:45
Articles in Press	2024-08-15 09:45
Publication Fee Transferred	2024-08-17 23:00
Edit the Manuscript by Language Editor	2024-08-20 17:43
Typeset the Manuscript	2024-08-22 00:30
Publish the Manuscript Online	2024-08-29 08:28

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	Successful cetuximab rechallenge in metastatic colorectal cancer: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Alexandra Guedes, Sandra Silva, Sandra Custódio and Andreia Capela
ORCID	Author(s) ORCID Number Alexandra Guedes http://orcid.org/0009-0005-1637-5207
Funding Agency and Grant Number
Corresponding Author	Alexandra Guedes, MD, Doctor, Doctor, Department of Medical Oncology, Centro Hospitalar Gaia/Espinho, Rua Conceição Fernandes S/N, Vila Nova de Gaia 4434-502, Portugal. alexandra.pereira.guedes@ulsge.min-saude.pt
Key Words	Metastatic colorectal cancer; RAS mutation; RAS wild type; Anti-epidermal growth factor receptor; Cetuximab; Rechallenge; Case report
Core Tip	In RAS-wild type patients treated with anti-epidermal growth factor receptor-inhibitors, the emergence of RAS mutations leads to resistance to further anti-epidermal growth factor receptor treatment. However, resistant clones seem to decay over time upon treatment withdrawal. Liquid biopsy-driven cetuximab rechallenge can be effective in later lines of treatment of metastatic colorectal cancer. Longer anti-epidermal growth factor receptor-free intervals may act as a surrogate for improved responses and survival outcomes.
Publish Date	2024-08-29 08:28
Citation	<p>Guedes A, Silva S, Custódio S, Capela A. Successful cetuximab rechallenge in metastatic colorectal cancer: A case report. <i>World J Clin Oncol</i> 2024; 15(9): 1232-1238</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i9/1232.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i9.1232

Full Article (PDF)	WJCO-15-1232-with-cover.pdf
CARE Checklist–2016	93717-CARE-Checklist-2016.pdf
Manuscript File	93717_Auto_Edited_082538.docx
Answering Reviewers	93717-answering-reviewers.pdf
Audio Core Tip	93717-audio.m4a
Conflict-of-Interest Disclosure Form	93717-conflict-of-interest-statement.pdf
Copyright License Agreement	93717-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93717-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	93717-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	93717-non-native-speakers.pdf
Peer-review Report	93717-peer-reviews.pdf
Scientific Misconduct Check	93717-scientific-misconduct-check.png
Scientific Editor Work List	93717-scientific-editor-work-list.pdf
CrossCheck Report	93717-crosscheck-report.pdf