Publication Name	World Journal of Clinical Oncology
Manuscript ID	9375
Country	United States

Received	2014-02-10 16:36
Peer-Review Started	2014-02-10 21:16
To Make the First Decision	2014-03-12 16:42
Return for Revision	2014-03-20 20:41
Revised	2014-05-07 06:46
Second Decision	2014-05-29 08:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 09:44
Articles in Press	2014-05-29 11:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-25 11:49
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Review of the current targeted therapies for non-small-cell lung cancer
Manuscript Source	Invited Manuscript
All Author List	Kim-Son H Nguyen, Joel W Neal and Heather Wakelee
Funding Agency and Grant Number
Corresponding Author	Heather Wakelee, MD, Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States. hwakelee@stanford.edu
Key Words	Lung cancer; Non-small cell lung cancer; Targeted therapies; Epidermal growth factor receptor; Epidermal growth factor receptor; Anaplastic lymphoma kinase; Acquired resistance
Core Tip	The development of oncogene-directed targeted therapies has significantly changed the treatment of non-small-cell lung cancer. We review the data demonstrating efficacy of small-molecule tyrosine kinase inhibitors against epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, and other oncogenes. We also discuss the challenge of acquired resistance to these therapies and review promising agents which may overcome resistance.
Publish Date	2014-08-01 16:16
Citation	Nguyen KSH, Neal JW, Wakelee H. Review of the current targeted therapies for non-small-cell lung cancer. World J Clin Oncol 2014; 5(4): 576-587
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/576.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.576

Full Article (PDF)	WJCO-5-576.pdf
Full Article (Word)	WJCO-5-576.doc
Manuscript File	9375-Review.docx
Answering Reviewers	9375-Answering reviewers.pdf
Copyright License Agreement	9375-Copyright assignment.pdf
Peer-review Report	9375-Peer review(s).pdf
Scientific Misconduct Check	9375-CrossCheck.jpg
Scientific Editor Work List	9375-Scientific editor work list.pdf